Iglesias R, Llobera M, Montoya E
Pharmacol Biochem Behav. 1986 Jun;24(6):1817-9. doi: 10.1016/0091-3057(86)90529-0.
The effect of long-term TRH administration through drinking water (0.2 mg/ml) on food and water intake and body weight has been studied in three groups of female rats: (1) thyroidectomized, (2) thyroidectomized receiving daily 250 micrograms/kg of L-T4, (3) sham-operated. Treatment with oral TRH for 30 days decreased body weight and increased food intake in sham-operated rats. No TRH effects on body weight or food consumption were observed in either of the other groups of thyroidectomized rats. TRH administration increased circulating T3 levels in sham-operated animals, but had no effects in either hypo- or hyperthyroid, thyroidectomized rats. It can be concluded that the TRH-induced increase on food intake is mediated through the pituitary-thyroid axis.
通过饮用水（0.2毫克/毫升）长期给予促甲状腺激素释放激素（TRH）对三组雌性大鼠的食物和水摄入量以及体重的影响已得到研究：（1）甲状腺切除的大鼠；（2）甲状腺切除且每日接受250微克/千克L - T4的大鼠；（3）假手术大鼠。对假手术大鼠口服TRH 30天会导致体重下降且食物摄入量增加。在其他两组甲状腺切除的大鼠中均未观察到TRH对体重或食物消耗有影响。给予TRH可使假手术动物的循环T3水平升高，但对甲状腺功能减退或亢进的甲状腺切除大鼠均无影响。可以得出结论，TRH诱导的食物摄入量增加是通过垂体 - 甲状腺轴介导的。
