Topf Ulrike, Drabikowski Krzysztof
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Front Neurosci. 2019 Mar 8;13:205. doi: 10.3389/fnins.2019.00205. eCollection 2019.
The nematode expresses the gene that encodes teneurin. TEN-1 protein is expressed throughout the life of . The loss of function results in embryonic and larval lethality, highlighting its importance for fundamental processes during development. TEN-1 is expressed in the epidermis and neurons. Defects in neuronal pathfinding and epidermal closure are characteristic of loss-of-function mutations. The molecular mechanisms of TEN-1 function in neurite outgrowth, neuronal pathfinding, and dendritic morphology in are largely unknown. Its genetic redundancy with the extracellular matrix receptors integrin and dystroglycan and genetic interactions with several basement membrane components suggest a role for TEN-1 in the maintenance of basement membrane integrity, which is essential for neuronal guidance. Identification of the gene in , which encodes latrophilin, as an interaction partner of provides further mechanistic insights into TEN-1 function in neuronal development. However, receptor-ligand interactions between LAT-1 and TEN-1 remain to be experimentally proven. The present review discusses the function of teneurin in , with a focus on its involvement in the formation of receptor signaling complexes and neuronal networks.
这种线虫表达编码teneurin的基因。TEN-1蛋白在其整个生命周期中都有表达。功能丧失会导致胚胎和幼虫致死，这突出了其在发育过程中基础过程的重要性。TEN-1在表皮和神经元中表达。神经元路径寻找和表皮闭合缺陷是功能丧失突变的特征。TEN-1在神经突生长、神经元路径寻找和树突形态中的分子机制在很大程度上尚不清楚。它与细胞外基质受体整合素和肌营养不良聚糖的基因冗余以及与几种基底膜成分的基因相互作用表明TEN-1在维持基底膜完整性中起作用，这对神经元导向至关重要。在该线虫中鉴定出编码latrophilin的基因作为其相互作用伴侣，为TEN-1在神经元发育中的功能提供了进一步的机制见解。然而，LAT-1和TEN-1之间的受体-配体相互作用仍有待实验证明。本综述讨论了teneurin在该线虫中的功能，重点关注其参与受体信号复合物和神经元网络的形成。
