• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卡巴拉汀透皮贴剂对疑似阿尔茨海默病患者睡眠呼吸暂停的影响。

The Effect of Rivastigmine Transdermal Patch on Sleep Apnea in Patients with Probable Alzheimer's Disease.

作者信息

Kim Hyeyun, Han Hyun Jeong

机构信息

Department of Neurology, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.

Department of Neurology, Myongji Hospital, Seonam University College of Medicine, Goyang, Korea.

出版信息

Dement Neurocogn Disord. 2016 Dec;15(4):153-158. doi: 10.12779/dnd.2016.15.4.153. Epub 2016 Dec 31.

DOI:10.12779/dnd.2016.15.4.153
PMID:30906358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6428022/
Abstract

BACKGROUND AND PURPOSE

This study was designed to evaluate the effect on sleep of rivastigmine transdermal patch in patients with probable Alzheimer's disease (AD).

METHODS

Patients with probable AD underwent a sleep questionnaire, overnight polysomnography and neuropsychological tests before and after rivastigmine transdermal patch treatment. We analyzed the data from enrolled patients with AD.

RESULTS

Fourteen patients with probable AD were finally enrolled in this study. The respiratory disturbance index after the rivastigmine patch treatment was improved in patients with probable AD and sleep breathing disorder, compared with that of before treatment (<0.05).

CONCLUSIONS

Rivastigmine transdermal patch application are expected to improve the symptoms of sleep disordered breathing in patients with probable AD. Further placebo controlled studies are needed to confirm these results.

摘要

背景与目的

本研究旨在评估卡巴拉汀透皮贴剂对疑似阿尔茨海默病（AD）患者睡眠的影响。

方法

疑似AD患者在接受卡巴拉汀透皮贴剂治疗前后进行睡眠问卷调查、夜间多导睡眠图检查和神经心理学测试。我们分析了纳入的AD患者的数据。

结果

最终有14例疑似AD患者纳入本研究。与治疗前相比，使用卡巴拉汀贴剂治疗后，疑似AD合并睡眠呼吸障碍患者的呼吸紊乱指数有所改善（<0.05）。

结论

卡巴拉汀透皮贴剂有望改善疑似AD患者的睡眠呼吸障碍症状。需要进一步的安慰剂对照研究来证实这些结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0005/6428022/fc2acfabdb42/dnd-15-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0005/6428022/fc2acfabdb42/dnd-15-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0005/6428022/fc2acfabdb42/dnd-15-153-g001.jpg

相似文献

1
The Effect of Rivastigmine Transdermal Patch on Sleep Apnea in Patients with Probable Alzheimer's Disease.卡巴拉汀透皮贴剂对疑似阿尔茨海默病患者睡眠呼吸暂停的影响。
Dement Neurocogn Disord. 2016 Dec;15(4):153-158. doi: 10.12779/dnd.2016.15.4.153. Epub 2016 Dec 31.
2
A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule.一项为期六个月的关于阿尔茨海默病透皮贴剂的双盲、随机、安慰剂对照研究——卡巴拉汀贴剂与胶囊剂对比。
Int J Geriatr Psychiatry. 2007 May;22(5):456-67. doi: 10.1002/gps.1788.
3
Efficacy of rivastigmine transdermal therapy on low food intake in patients with Alzheimer's disease: The Attitude Towards Food Consumption in Alzheimer's Disease Patients Revive with Rivastigmine Effects study.多奈哌齐透皮贴剂治疗阿尔茨海默病患者低食欲的疗效：多奈哌齐对阿尔茨海默病患者摄食态度影响的研究。
Geriatr Gerontol Int. 2019 Jul;19(7):571-576. doi: 10.1111/ggi.13644. Epub 2019 Mar 12.
4
Rivastigmine transdermal patch skin tolerability: results of a 1-year clinical trial in patients with mild-to-moderate Alzheimer's disease.重酒石酸卡巴拉汀透皮贴剂的皮肤耐受性：轻度至中度阿尔茨海默病患者 1 年临床试验结果。
Clin Drug Investig. 2010;30(1):41-9. doi: 10.2165/11531270-000000000-00000.
5
Rivastigmine transdermal patch and capsule in Alzheimer's disease: influence of disease stage on response to therapy.利斯的明透皮贴剂和胶囊治疗阿尔茨海默病：疾病阶段对治疗反应的影响。
Int J Geriatr Psychiatry. 2011 Dec;26(12):1236-43. doi: 10.1002/gps.2669. Epub 2010 Dec 23.
6
A 24-week, multicentre, open evaluation of the clinical effectiveness of the rivastigmine patch in patients with probable Alzheimer's disease.一项为期 24 周、多中心、开放性评估rivastigmine 贴片对可能患有阿尔茨海默病患者的临床疗效的研究。
Int J Clin Pract. 2011 Jul;65(7):790-6. doi: 10.1111/j.1742-1241.2011.02713.x. Epub 2011 Jun 6.
7
Dose effects associated with rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer's disease.与利伐斯的明透皮贴剂相关的剂量效应在轻度至中度阿尔茨海默病患者中。
Int J Clin Pract. 2011 Apr;65(4):465-71. doi: 10.1111/j.1742-1241.2011.02641.x. Epub 2011 Feb 11.
8
Rivastigmine for Alzheimer's disease.卡巴拉汀用于治疗阿尔茨海默病。
Cochrane Database Syst Rev. 2009 Apr 15(2):CD001191. doi: 10.1002/14651858.CD001191.pub2.
9
Response to rivastigmine transdermal patch or memantine plus rivastigmine patch is affected by apolipoprotein E genotype in Alzheimer patients.阿尔茨海默病患者对利斯的明透皮贴剂或美金刚联合利斯的明透皮贴剂的反应受载脂蛋白 E 基因型的影响。
Dement Geriatr Cogn Disord. 2012;34(3-4):167-73. doi: 10.1159/000342927. Epub 2012 Oct 5.
10
A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease.一项评估卡巴拉汀透皮贴剂与认知刺激综合治疗对阿尔茨海默病患者疗效的前瞻性随机对照试验。
Int J Geriatr Psychiatry. 2015 Sep;30(9):965-75. doi: 10.1002/gps.4247. Epub 2014 Dec 12.

引用本文的文献

1
Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders.从临床前研究到临床试验：用于神经退行性和精神疾病的经皮药物传递。
Pharm Res. 2024 Jun;41(6):1045-1092. doi: 10.1007/s11095-024-03718-x. Epub 2024 Jun 11.

本文引用的文献

1
Pharmacologic Approaches to the Treatment of Obstructive Sleep Apnea.阻塞性睡眠呼吸暂停的药物治疗方法
Sleep Med Clin. 2016 Jun;11(2):203-12. doi: 10.1016/j.jsmc.2016.01.007. Epub 2016 Apr 8.
2
Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease.睡眠与患有和未患有阿尔茨海默病的老年人腹外侧视前区/中间核中的神经元数量有关。
Brain. 2014 Oct;137(Pt 10):2847-61. doi: 10.1093/brain/awu222. Epub 2014 Aug 20.
3
Beneficial effect of donepezil on obstructive sleep apnea: a double-blind, placebo-controlled clinical trial.
多奈哌齐对阻塞性睡眠呼吸暂停的有益作用：一项双盲、安慰剂对照临床试验。
Sleep Med. 2012 Mar;13(3):290-6. doi: 10.1016/j.sleep.2011.09.014. Epub 2012 Jan 26.
4
Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease.在可能患有阿尔茨海默病的患者中，从口服胆碱酯酶抑制剂转换为利斯的明透皮贴剂的疗效和安全性。
J Clin Neurol. 2011 Sep;7(3):137-42. doi: 10.3988/jcn.2011.7.3.137. Epub 2011 Sep 29.
5
Reviews: Effects of transdermal rivastigmine on ADAS-cog items in mild-to-moderate Alzheimer's disease.评论：透皮利伐斯的明对轻中度阿尔茨海默病 ADAS-cog 项目的影响。
Am J Alzheimers Dis Other Demen. 2010 Dec;25(8):627-33. doi: 10.1177/1533317510385808.
6
Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes.帕金森综合征患者大脑皮质和皮质下胆碱能缺失。
Neurology. 2010 May 4;74(18):1416-23. doi: 10.1212/WNL.0b013e3181dc1a55.
7
Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary study.持续使用 CPAP 可减缓阿尔茨海默病合并阻塞性睡眠呼吸暂停患者的认知、睡眠和情绪恶化：一项初步研究。
J Clin Sleep Med. 2009 Aug 15;5(4):305-9.
8
Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer's disease: a review.新型透皮利斯的明贴片治疗阿尔茨海默病的药代动力学：综述。
Int J Clin Pract. 2009 May;63(5):799-805. doi: 10.1111/j.1742-1241.2009.02052.x.
9
Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease.卡巴拉汀透皮贴剂在阿尔茨海默病治疗中的应用。
Expert Opin Drug Deliv. 2008 Dec;5(12):1377-86. doi: 10.1517/17425240802542690.
10
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.治疗阿尔茨海默病阻塞性睡眠呼吸暂停的认知效应：一项随机对照研究。
J Am Geriatr Soc. 2008 Nov;56(11):2076-81. doi: 10.1111/j.1532-5415.2008.01934.x. Epub 2008 Sep 15.