Unger E, Böhm K J, Vater W
Acta Histochem Suppl. 1986;33:85-94.
The pathway of tubulin assembly is controlled by a lot of effectors. We summarize some of these effectors favouring the formation of microtubules or inducing several MT-aberrant, polymorphic structures. Both in vivo and in vitro, microtubules with different protofilament numbers were found. In vivo, microtubules are composed of 11-16 protofilaments. The protofilament number of microtubules formed in vitro varies from 8-17. We describe some effectors responsible for the diversity of the protofilament number in microtubules. Moreover, differences in the amino acid sequences of distinct tubulins should be taken into account, too. The protofilament number of an established microtubule can be still altered if activities of effectors or microenvironmental conditions are changed. Thus, the protofilament number of microtubules is a dynamic property based on the permanent tubulin exchange.
微管蛋白组装途径受多种效应物控制。我们总结了其中一些促进微管形成或诱导几种微管异常、多态结构的效应物。在体内和体外均发现了具有不同原纤维数量的微管。在体内，微管由11 - 16条原纤维组成。体外形成的微管的原纤维数量在8 - 17条之间变化。我们描述了一些导致微管中原纤维数量多样性的效应物。此外，不同微管蛋白的氨基酸序列差异也应予以考虑。如果效应物的活性或微环境条件发生变化，已形成的微管的原纤维数量仍可能改变。因此，微管的原纤维数量是基于微管蛋白不断交换的动态特性。
