Cao Junjie, Hou Rui, Lu Jingqian, Zhang Kongyan, Zhao Cui, Jiang Haisen, Feng Yumei, Wang Yiwei
Department of Geriatrics, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.
Department of Cardiology, The First Hospital of Kunming, Kunming, Yunnan 650000, P.R. China.
Exp Ther Med. 2019 Apr;17(4):3065-3070. doi: 10.3892/etm.2019.7278. Epub 2019 Feb 14.
Predictive value of β2-microglobulin (β2-MG) and transforming growth factor-β (TGF-β) for elderly hypertensive nephropathy was investigated. The clinical data of 56 patients with hypertensive nephropathy and admitted to Affiliated Hospital of Chengde Medical College from December 2015 to December 2017, were retrospectively analyzed and the clinical data were used as the study group, the clinical data of 50 patients with hypertension, but not nephropathy, were selected as the control group. The expression levels of β2-MG and TGF-β in the serum were detected by ELISA. The correlation between β2-MG and TGF-β was analyzed by Pearson's correlation. The sensitivity and specificity of β2-MG, TGF-β and combined application in the diagnosis of hypertensive nephropathy were analyzed by ROC curve. The expression levels of β2-MG and TGF-β in the serum of the patients in the study group were significantly higher than those in the control group (P<0.001). There was a positive correlation between the expression levels of β2-MG and TGF-β in the serum of the patients in the study group (r=0.619, P<0.001). The AUC of β2-MG in the diagnosis of hypertensive nephropathy was 0.786. The AUC of TGF-β in the diagnosis of hypertensive nephropathy was 0.793. The AUC of the combined application of β2-MG and TGF-β in the diagnosis of hypertensive nephropathy was 0.860. β2-MG and TGF-β were highly expressed in the patients with hypertensive nephropathy, and the expression levels of β2-MG and TGF-β were positively correlated (r=0.619, P<0.001). The combined application of β2-MG and TGF-β in the diagnosis of hypertensive nephropathy could reduce or even avoid the missed diagnosis caused by single detection. The two indicators complemented and confirmed each other, which had a great significance for improving the positive diagnosis rate of hypertensive nephropathy.
研究了β2微球蛋白（β2-MG）和转化生长因子-β（TGF-β）对老年高血压肾病的预测价值。回顾性分析2015年12月至2017年12月在承德医学院附属医院住院的56例高血压肾病患者的临床资料，并将其作为研究组，选取50例高血压但无肾病患者的临床资料作为对照组。采用酶联免疫吸附测定法检测血清中β2-MG和TGF-β的表达水平。采用Pearson相关性分析β2-MG与TGF-β的相关性。采用ROC曲线分析β2-MG、TGF-β及联合应用对高血压肾病诊断的敏感性和特异性。研究组患者血清中β2-MG和TGF-β的表达水平显著高于对照组（P<0.001）。研究组患者血清中β2-MG与TGF-β的表达水平呈正相关（r=0.619，P<0.001）。β2-MG诊断高血压肾病的曲线下面积（AUC）为0.786。TGF-β诊断高血压肾病的AUC为0.793。β2-MG与TGF-β联合应用诊断高血压肾病的AUC为0.860。β2-MG和TGF-β在高血压肾病患者中高表达，且β2-MG与TGF-β的表达水平呈正相关（r=0.619，P<0.001）。β2-MG与TGF-β联合应用于高血压肾病的诊断可减少甚至避免单指标检测导致的漏诊。二者相互补充、相互印证，对提高高血压肾病的阳性诊断率具有重要意义。
