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开发一种独立的图形用户界面,用于通过自动提取和分割脑 MRI 图像中的灰质和白质来预测神经疾病。

Development of a Stand-Alone Independent Graphical User Interface for Neurological Disease Prediction with Automated Extraction and Segmentation of Gray and White Matter in Brain MRI Images.

机构信息

Texas A&M University-Kingsville, Kingsville, Texas, USA.

G. L. Bajaj Institute of Technology and Management, Greater Noida, UP, India.

出版信息

J Healthc Eng. 2019 Feb 14;2019:9610212. doi: 10.1155/2019/9610212. eCollection 2019.

Abstract

This research presents an independent stand-alone graphical computational tool which functions as a neurological disease prediction framework for diagnosis of neurological disorders to assist neurologists or researchers in the field to perform automatic segmentation of gray and white matter regions in brain MRI images. The tool was built in collaboration with neurologists and neurosurgeons and many of the features are based on their feedback. This tool provides the user automatized functionality to perform automatic segmentation and extract the gray and white matter regions of patient brain image data using an algorithm called adapted fuzzy -means (FCM) membership-based clustering with preprocessing using the elliptical Hough transform and postprocessing using connected region analysis. Dice coefficients for several patient brain MRI images were calculated to measure the similarity between the manual tracings by experts and automatic segmentations obtained in this research. The average Dice coefficients are 0.86 for gray matter, 0.88 for white matter, and 0.87 for total cortical matter. Dice coefficients of the proposed algorithm were also the highest when compared with previously published standard state-of-the-art brain MRI segmentation algorithms in terms of accuracy in segmenting the gray matter, white matter, and total cortical matter.

摘要

本研究提出了一个独立的图形计算工具,作为一种神经疾病预测框架,用于诊断神经紊乱,以帮助神经科医生或该领域的研究人员对脑 MRI 图像进行自动灰白质区域分割。该工具是与神经科医生和神经外科医生合作开发的,其许多功能都是基于他们的反馈。该工具为用户提供了自动化功能,使用一种名为基于自适应模糊均值(FCM)隶属度聚类的算法,通过椭圆哈夫变换进行预处理,并使用连通区域分析进行后处理,从而对患者脑图像数据进行自动分割,并提取灰白质区域。针对几个患者的脑 MRI 图像计算了 Dice 系数,以衡量专家手动追踪与本研究中获得的自动分割之间的相似性。灰质的平均 Dice 系数为 0.86,白质为 0.88,总皮质为 0.87。与之前发表的标准最先进的脑 MRI 分割算法相比,该算法在分割灰质、白质和总皮质方面的准确性方面,其 Dice 系数也是最高的。

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