Dickson Eamonn James
Department Physiology and Membrane Biology, University of California, Davis, CA, 95616, USA.
F1000Res. 2019 Mar 12;8. doi: 10.12688/f1000research.16679.1. eCollection 2019.
Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane-cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.
多磷酸肌醇（PPIn）是重要的信号磷脂，对哺乳动物细胞中所有细胞膜的特性和信号级联反应都有显著贡献。它们通过在膜 - 细胞质界面与细胞蛋白的选择性相互作用，对膜稳态发挥调节控制作用。这篇综述文章简要总结了我们目前对PPIn在协调和调节哺乳动物神经元中关键的电信号和化学信号事件所起的关键作用，以及其代谢改变后出现的重大神经病理生理状况的理解。
