Bistriceanu M, Roşca T R, Mocanu I, Bistriceanu I, Voinea F
Endocrinologie. 1986 Apr-Jun;24(2):109-13.
The study was carried out on 21 female hyperthyroid patients aged 22-53 years, with or without associated ophthalmopathy, admitted to the Endocrinology ward of the 1st Medical Clinic of the Craiova County Hospital, Romania, between 1983 and 1985. Administration of lithium carbonate was proceeded and followed by radioimmunoassay (RIA) determinations of T3 and T4 and measurement of Achilles' reflex (AR). Two regimens were employed. The first comprised ten patients receiving doses of 500 mg/day lithium carbonate and the second 11 patients who had an associated ophthalmopathy and who received 250 mg/day lithium carbonate and 30 mg/day carbimazole. Lithium administration was discontinued after 4 weeks. The results of the therapy suggest a possible intervention of lithium carbonate in the process of blocking the biosynthesis of thyroid hormones and/or its regulating processes, with concomitant improvement of the clinical status, much more in the patients without ophthalmopathy.
该研究针对1983年至1985年间收治于罗马尼亚克拉约瓦县医院第一医疗诊所内分泌科病房的21名年龄在22至53岁之间的女性甲亢患者进行，这些患者伴有或不伴有相关眼病。给予碳酸锂治疗，随后通过放射免疫分析（RIA）测定T3和T4，并测量跟腱反射（AR）。采用了两种治疗方案。第一种方案包括10名接受每日500毫克碳酸锂剂量的患者，第二种方案包括11名伴有眼病且接受每日250毫克碳酸锂和30毫克卡比马唑的患者。4周后停止给予碳酸锂。治疗结果表明碳酸锂可能干预了甲状腺激素生物合成过程及其调节过程，同时临床状况有所改善，在无眼病的患者中改善更为明显。
