Liu Jianting, Wang Xiaogang, Wang Jinfeng, Guo Haike
Southern Medical University, Guangzhou, Guangdong, China.
Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Optom Vis Sci. 2019 Apr;96(4):248-255. doi: 10.1097/OPX.0000000000001360.
This study suggests that despite having comparable best-corrected visual acuity and normal fundus appearance, objective measurements of optical quality showed that patients with diabetes but without overt retinopathy may have impaired visual function. Screening using the Optical Quality Analysis System might help identify those patients.
Visual impairments are common in diabetes, but the status of the problem is unclear before the development of diabetic retinopathy. The aim of this pilot study was to investigate the optical quality and intraocular scattering in the diabetic eye without diabetic retinopathy.
Twenty-seven patients with diabetes without diabetic retinopathy were enrolled. Twenty-seven age- and sex-matched healthy volunteers served as a control group. Optical quality parameters included modulation transfer function cutoff frequency, Strehl (two-dimensional) ratio, and Optical Quality Analysis System values at 100, 20, and 9 contrast levels. The objective scatter index was assessed using the Optical Quality Analysis System. Correlations were analyzed between the modulation transfer function cutoff, Strehl ratio, objective scatter index, and Optical Quality Analysis System value, and the age of the patient and the duration of diabetes mellitus.
The diabetic group exhibited lower modulation transfer function cutoff, Strehl ratio, and Optical Quality Analysis System values at 100, 20, and 9% contrast levels and higher objective scatter index than did the controls (all, P < .01). There were no associations between the optical quality parameters and age or the duration of diabetes mellitus in the diabetic participants (all, P > .05). Moderate associations were found between all parameters obtained from the Optical Quality Analysis System and age in the control group (all, P < .01).
This pilot study suggests that optical quality was reduced, and intraocular scattering increased in the diabetic eye without diabetic retinopathy compared with controls.
本研究表明，尽管糖尿病患者的最佳矫正视力相当且眼底外观正常，但光学质量的客观测量显示，患有糖尿病但无明显视网膜病变的患者可能存在视觉功能受损。使用光学质量分析系统进行筛查可能有助于识别这些患者。
视力损害在糖尿病患者中很常见，但在糖尿病视网膜病变发生之前，问题的状况尚不清楚。本试点研究的目的是调查无糖尿病视网膜病变的糖尿病患者眼睛的光学质量和眼内散射情况。
招募了27名无糖尿病视网膜病变的糖尿病患者。27名年龄和性别匹配的健康志愿者作为对照组。光学质量参数包括调制传递函数截止频率、斯特列尔（二维）比率以及在100%、20%和9%对比度水平下的光学质量分析系统值。使用光学质量分析系统评估客观散射指数。分析调制传递函数截止值、斯特列尔比率、客观散射指数和光学质量分析系统值与患者年龄和糖尿病病程之间的相关性。
糖尿病组在100%、20%和9%对比度水平下的调制传递函数截止值、斯特列尔比率和光学质量分析系统值均低于对照组，且客观散射指数高于对照组（均P < 0.01）。糖尿病参与者的光学质量参数与年龄或糖尿病病程之间无关联（均P > 0.05）。在对照组中，从光学质量分析系统获得的所有参数与年龄之间存在中度关联（均P < 0.01）。
本试点研究表明，与对照组相比，无糖尿病视网膜病变的糖尿病患者眼睛的光学质量降低，眼内散射增加。
