达菲血型系统的最新情况。

An update on the Duffy blood group system.

作者信息

Meny Geralyn M

机构信息

Director, Medical Affairs, Diagnostics USA.

出版信息

Immunohematology. 2019 Jan;35(1):11-12.

PMID:30908072

Abstract

This update of the Duffy (FY) blood group system (Meny GM. The Duffy blood group system: a review. Immunohematology 2010;26:51-6) includes additional variants to the Duffy system (International Society of Blood Transfusion system 8; five anti-gens) identified through molecular studies. The most interesting clinical updates, however, include further evaluation of the roles of the Duffy glycoprotein, also known as the atypical chemokine receptor 1, in malaria and hematopoiesis. The transition to understanding the important role of blood group antigens in homeostasis and disease continues.

摘要

达菲（FY）血型系统的这一更新内容（Meny GM. 达菲血型系统综述。免疫血液学2010；26：51 - 6）纳入了通过分子研究确定的达菲系统（国际输血协会系统8；五种抗原）的更多变体。然而，最有趣的临床进展包括对达菲糖蛋白（也称为非典型趋化因子受体1）在疟疾和造血过程中作用的进一步评估。对血型抗原在体内平衡和疾病中的重要作用的认识仍在不断深入。