伊朗东南部巴乌尔赫人群间日疟原虫患者的达菲血型基因型

Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.

作者信息

Miri-Moghaddam Ebrahim, Bameri Zakaria, Mohamadi Mehdi

机构信息

Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Genetics, Zahedan University of Medical Sciences, Zahedan, Iran.

Infections and Tropical Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

出版信息

Asian Pac J Trop Med. 2014 Mar;7(3):206-7. doi: 10.1016/S1995-7645(14)60021-3.

DOI:10.1016/S1995-7645(14)60021-3

PMID:24507640

Abstract

OBJECTIVE

To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran.

METHODS

In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control individuals.

RESULTS

The results showed that the most common Duffy genotype was FYA/FYB (46.6%) followed by FYA/FYA (15.3%), FYA/FYO (14.4%), FYB/FYO (11.9%), FYB/FYB (10%) and FYO/FYO (1.9%). In case individuals, frequency of FYA, FYB and FYO alleles were 0.471, 0.431 and 0.097, respectively compaired to 0.444, 0.353 and 0.203, respectively in control (non-infected) group.

CONCLUSIONS

This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.

摘要

目的

确定俾路支人群中达菲血型基因型的分布情况，俾路支人群是生活在伊朗东南部亚热带地区的主要族群。

方法

在本研究中，采用间接抗球蛋白技术确定160例间日疟患者和160例对照个体的达菲血型FY表型，并通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定基因型。

结果

结果显示，最常见的达菲基因型是FYA/FYB（46.6%），其次是FYA/FYA（15.3%）、FYA/FYO（14.4%）、FYB/FYO（11.9%）、FYB/FYB（10%）和FYO/FYO（1.9%）。在病例个体中，FYA、FYB和FYO等位基因的频率分别为0.471、0.431和0.097，而在对照（未感染）组中分别为0.444、0.353和0.203。