18F-FDG PET/CT在软组织肉瘤中的作用。
The role of 18F-FDG PET/CT in soft tissue sarcoma.
作者信息
Sambri Andrea, Bianchi Giuseppe, Longhi Alessandra, Righi Alberto, Donati Davide Maria, Nanni Cristina, Fanti Stefano, Errani Costantino
机构信息
IRCCS Rizzoli Orthopaedic Institute.
Department of DIBINEM University of Bologna, Bologna, Italy.
出版信息
Nucl Med Commun. 2019 Jun;40(6):626-631. doi: 10.1097/MNM.0000000000001002.
INTRODUCTION
Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Our aim was to evaluate F-FDG uptake in different STS types and to assess the prognostic value of the maximum standardized uptake value (SUVmax).
PATIENTS AND METHODS
We reviewed 50 adult patients with primary high-grade STS of the extremities with a preoperative PET. Overall survival and local recurrence were analysed.
RESULTS
The mean SUVmax was 12.9 (range: 2.2-33.4). All cases of myxoid liposarcoma and all cases of synovial sarcoma had SUVmax of less than 10.3. A better overall survival and local recurrence were observed in patients with SUVmax of less than 10.3 (P=0.005 and 0.046, respectively).
CONCLUSION
SUVmax seems to be specific among different STS histotypes. PET does not seem to be useful in myxoid liposarcoma as well as synovial sarcoma as these tumours seem to have a low uptake of glucose. SUVmax might also be included as a prognostic factor.
引言
软组织肉瘤（STS）是高度摄取氟-18-氟脱氧葡萄糖（F-FDG）的肿瘤。正电子发射断层显像（PET）似乎对评估疾病范围有效。然而，使用PET将STS分层为不同风险组织学类型仍存在争议。我们的目的是评估不同类型STS中F-FDG的摄取情况，并评估最大标准化摄取值（SUVmax）的预后价值。
患者与方法
我们回顾性分析了50例术前接受PET检查的成人原发性肢体高级别STS患者。分析总生存期和局部复发情况。
结果
平均SUVmax为12.9（范围：2.2 - 33.4）。所有黏液样脂肪肉瘤病例和所有滑膜肉瘤病例的SUVmax均小于10.3。SUVmax小于10.3的患者总生存期和局部复发情况较好（分别为P = 0.005和0.046）。
结论
SUVmax在不同的STS组织学类型中似乎具有特异性。PET在黏液样脂肪肉瘤和滑膜肉瘤中似乎无用，因为这些肿瘤似乎对葡萄糖摄取较低。SUVmax也可能作为一个预后因素。
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