Jelloul Fatima-Zahra, Navarro Maria, Navale Pooja, Hagan Tamla, Cocker Rubina S, Das Kasturi, Rosen Lisa, Zhang Xinmin, Sheikh-Fayyaz Silvat
Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.
The Feinstein Institute for Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.
Acta Cytol. 2019;63(3):198-205. doi: 10.1159/000497252. Epub 2019 Mar 25.
The objective is to study the efficacy of fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB) in the diagnosis of lymphoma in a single institution.
We retrospectively reviewed 635 FNAB/CNB cases performed in our institution to rule out lymphoma during a 4-year period and collected the relevant clinical and pathological information for statistical analysis.
This cohort comprised 275 males and 360 females, with a median age of 57 years. Among the 593 cases with adequate diagnostic materials for lymphoma work-up, 226 were positive for lymphoma, 286 were negative for lymphoma, and 81 were nondiagnostic. Each case had an FNAB, and 191 cases also underwent a CNB. The subclassification rate according to the WHO (2008) was 67% overall, 81% for the FNAB with CNB group, and 40% for the FNAB group. In the FNAB with CNB group, the subclassification rates for cases with and without a history of lymphoma were not significantly different. A definitive diagnosis of lymphoma relied on ancillary studies, but was not affected by location, or the needle gauge of CNB. Follow-up data revealed a high diagnostic accuracy of FNAB with CNB. In conclusion, the use of FNAB and CNB with ancillary studies is effective in providing a definitive diagnosis of lymphoma in our experience at the Northwell Health System.
本研究旨在探讨细针穿刺活检（FNAB）和粗针穿刺活检（CNB）在单机构诊断淋巴瘤中的疗效。
我们回顾性分析了本机构在4年期间为排除淋巴瘤而进行的635例FNAB/CNB病例，并收集了相关临床和病理信息进行统计分析。
该队列包括275名男性和360名女性，中位年龄为57岁。在593例有足够诊断材料用于淋巴瘤检查的病例中，226例淋巴瘤阳性，286例淋巴瘤阴性，81例诊断不明确。每例均进行了FNAB，191例还进行了CNB。根据世界卫生组织（2008年）的分类率总体为67%，FNAB联合CNB组为81%，FNAB组为40%。在FNAB联合CNB组中，有和无淋巴瘤病史的病例分类率无显著差异。淋巴瘤的明确诊断依赖于辅助检查，但不受CNB的部位或针径影响。随访数据显示FNAB联合CNB具有较高的诊断准确性。总之，根据我们在诺斯韦尔健康系统的经验，使用FNAB和CNB并结合辅助检查可有效明确淋巴瘤的诊断。
