Zhang Y, Piao Y S, Zhang L
Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Mar 7;54(3):227-231. doi: 10.3760/cma.j.issn.1673-0860.2019.03.014.
IgG4 related disease (IgG4-RD) is an independent clinical pathological entity which is different from common chronic inflammation and other autoimmune diseases in recent years. It often appears in the form of tumor like tissue-destructive lesions and may be accompanied by the increase of concentration of serum IgG4. Histopathology is characterized by a large number of lymphocytes and plasma cells infiltration, storiform fibrosis and occlusive phlebitis. The characteristics of IgG4-RD in nose and sinuses have not been widely investigated. The aim of the present study is to review the advances in IgG4 related sinonasal diseases from four aspects including pathogenesis, clinical features, treatment and future research directions.
IgG4相关性疾病（IgG4-RD）是一种独立的临床病理实体，近年来不同于常见的慢性炎症和其他自身免疫性疾病。它常以肿瘤样组织破坏性病变的形式出现，可能伴有血清IgG4浓度升高。组织病理学特征为大量淋巴细胞和浆细胞浸润、席纹状纤维化和闭塞性静脉炎。IgG4-RD在鼻和鼻窦的特征尚未得到广泛研究。本研究的目的是从发病机制、临床特征、治疗及未来研究方向四个方面综述IgG4相关性鼻鼻窦疾病的研究进展。
