Jaller Jose A., Borda Luis J., Kirsner Robert S.
J Drugs Dermatol. 2019 Mar 1;18(3):301-302.
Erosive pustular dermatosis is a rare inflammatory skin disorder characterized by crusted erosions, sterile pustules, skin atrophy, and scarring alopecia. Cases of involvement of lower extremities, with or without scalp lesions, have been scarcely reported in the literature, and have been denominated Erosive Pustular Dermatosis of the Legs. The disorder usually affects elderly patients associated with chronic venous insufficiency and venous dermatitis. Topical corticosteroids and topical calcineurin inhibitors have been reported to be effective. On the other hand, several treatments have also failed to achieve appropriate results; hence we present a case of erosive pustular dermatosis of the leg, who was unresponsive to compression and antibacterial ointments, but successfully treated systemically with an oral retinoid and locally with the application of a bioengineered bi-layered skin substitute. This condition may be overlooked, which represents its low prevalence in literature. J Drugs Dermatol. 2019;18(3):301-302.
糜烂性脓疱性皮肤病是一种罕见的炎症性皮肤病，其特征为结痂性糜烂、无菌性脓疱、皮肤萎缩和瘢痕性脱发。下肢受累病例，无论有无头皮病变，在文献中鲜有报道，被称为腿部糜烂性脓疱性皮肤病。该疾病通常影响伴有慢性静脉功能不全和静脉性皮炎的老年患者。据报道，外用糖皮质激素和外用钙调神经磷酸酶抑制剂有效。另一方面，几种治疗方法也未能取得理想效果；因此，我们报告一例腿部糜烂性脓疱性皮肤病患者，该患者对压迫和抗菌软膏治疗无效，但口服维甲酸全身治疗并局部应用生物工程双层皮肤替代物后成功治愈。这种疾病可能被忽视，这也是其在文献中患病率较低的原因。《药物皮肤病学杂志》。2019年；18(3):301 - 302。
