Torigoe Tomoaki, Imanishi Jungo, Yazawa Yasuo, Kadono Yuho, Oda Hiromi
1 Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
2 Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan.
J Orthop Surg (Hong Kong). 2019 May-Aug;27(2):2309499019838124. doi: 10.1177/2309499019838124.
It is unclear whether antecedent primary malignancies (APMs) have any negative impact on the prognosis of soft tissue sarcoma (STS). We retrospectively reviewed STS patients with APMs (STS-APM) and compared their survival to those of STS only (STS-O).
Twenty-one cases of STS-APM from 2008 to 2017 in our institution were analyzed. One hundred and seventy cases of STS-O at the same period were compared as a control group. Overall survival was estimated using Kaplan-Meier survival curves and prognostic factors were analyzed using logistic regression analyses and contingency table analyses.
As the final status of STS-APM patients, 12 patients were in disease-free survival, 5 were alive with disease, 3 have died of disease, and 1 has died of another disease. There was no case that died of APM. The 5-year overall survival rates were 88% in STS-APM and 78% in STS-O, showing no statistical significant ( p = 0.65). The 5-year overall survival rates in each stage of STS-APM and STS-O were 100/100% in stage I, 100/85% in stage II, 86/72% in stage III, and the 3-year overall survival rates were 67/51% in stage IV, with no statistical significance. With regard to prognostic factor, histological grade of STS was the only significant factor. Although antecedent radiotherapy tended to show a high odds ratio, the association was not statistically significant. Antecedent chemotherapy did not show any estimated prognostic risk.
Our study suggested that APM in STS patient would not be a negative prognostic factor.
既往原发性恶性肿瘤（APM）是否对软组织肉瘤（STS）的预后有负面影响尚不清楚。我们回顾性分析了患有APM的STS患者（STS - APM），并将他们的生存率与单纯STS患者（STS - O）进行比较。
分析了2008年至2017年在我院的21例STS - APM病例。同期170例STS - O病例作为对照组。采用Kaplan - Meier生存曲线估计总生存率，并采用逻辑回归分析和列联表分析来分析预后因素。
作为STS - APM患者的最终状态，12例患者无病生存，5例带瘤生存，3例死于疾病，1例死于其他疾病。没有患者死于APM。STS - APM的5年总生存率为88%，STS - O为78%，无统计学意义（p = 0.65）。STS - APM和STS - O各阶段的5年总生存率在I期为100/100%，II期为100/85%，III期为86/72%，IV期的3年总生存率为67/51%，均无统计学意义。关于预后因素，STS的组织学分级是唯一的显著因素。虽然既往放疗倾向于显示高比值比，但该关联无统计学意义。既往化疗未显示任何估计的预后风险。
我们的研究表明，STS患者中的APM不是一个负面的预后因素。
