原发性腹膜癌肉瘤：两例报告。
Primary peritoneal carcinosarcoma: A report of two cases.
作者信息
Fu Hao-Sheng, Wu Yen-Chen, Chen Ching-Hui, Liu Wei-Min, Cheng Chien-Jui, Chang Ching-Wen, Wang I-De, Chiu Yen-Hsieh
机构信息
Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
Department of Pathology, Taipei Medical University Hospital, Taipei, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2019 Mar;58(2):288-291. doi: 10.1016/j.tjog.2018.12.001.
OBJECTIVE
Carcinosarcomas also known as malignant mixed mullerian tumors (MMMTs) contain both carcinomatous and sarcomatous elements. Most MMMTs are arising from female genital tract, including ovaries, uterus and fallopian tubes. Extragenital carcinosarcomas are extremely rare, with an estimation less than 40 cases so far.
CASE REPORT
We report two cases of primary peritoneal carcinosarcomas. An 81-year-old woman with pelvic peritoneal carcinosarcoma, heterologous type, was treated with incomplete surgery without further chemotherapy, and died of disease soon. The other one was a 76 year-old woman with abdominal peritoneal carcinosarcoma, homologous type. After optimal debulking surgery and subsequent 6 cycles of combination of paclitaxel and carboplatin chemotherapy, the patient is free of tumor half of year.
CONCLUSION
Active therapy, including complete cytoreduction surgery and carboplatin-paclitaxel chemotherapy might offer a chance of disease control for these unusual primary peritoneal carcinosarcomas.
目的
癌肉瘤又称恶性米勒管混合瘤（MMMTs），包含癌性和肉瘤性成分。大多数MMMTs起源于女性生殖道，包括卵巢、子宫和输卵管。生殖器外癌肉瘤极为罕见，据估计迄今为止病例不足40例。
病例报告
我们报告两例原发性腹膜癌肉瘤。一名81岁患有盆腔腹膜癌肉瘤（异源型）的女性接受了不完全手术，未进行进一步化疗，很快死于疾病。另一例是一名76岁患有腹部腹膜癌肉瘤（同源型）的女性。在进行了最佳减瘤手术后，随后接受了6个周期的紫杉醇和卡铂联合化疗，该患者半年内无肿瘤。
结论
积极的治疗，包括完全细胞减灭术和卡铂-紫杉醇化疗，可能为这些不常见的原发性腹膜癌肉瘤提供疾病控制的机会。
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