Cancer Discov. 2019 May;9(5):568-569. doi: 10.1158/2159-8290.CD-NB2019-042. Epub 2019 Mar 25.
In mid-March, the FDA approved the PD-L1 inhibitor atezolizumab in combination with carboplatin and etoposide as a first-line therapy for small cell lung cancer. The approval was based on results from the phase III IMpower133 trial in which adding atezolizumab to chemotherapy extended overall and progression-free survival.
3月中旬,美国食品药品监督管理局(FDA)批准程序性死亡受体配体1(PD-L1)抑制剂阿替利珠单抗与卡铂和依托泊苷联合使用,作为小细胞肺癌的一线治疗方案。该批准基于III期IMpower133试验的结果,在该试验中,化疗中加入阿替利珠单抗可延长总生存期和无进展生存期。