Mukhamedjanova N I, Aripov O A
Tashkent Institute of Postgraduate medical education, Tashkent, 100007, Uzbekistan.
Klin Lab Diagn. 2019;64(1):42-45. doi: 10.18821/0869-2084-2019-64-1-42-45.
The purpose of this study was to assess the quality of laboratory research, its problem areas and potential improvements using the example of a number of regional clinical diagnostic laboratories in the Tashkent region and the comparability of laboratory analysis data obtained in various laboratories. We have evaluated the quality of laboratory tests in 40 clinical diagnostic laboratories of the Tashkent region. The control was carried out on 9 biochemical parameters of blood. In our studies using the control serum, the results were deplorable: the error was 50% in determining the OB and glucose, and the correct results were obtained in only 30% of the laboratories; biliru-bin - unreliable results were issued in 40% of laboratories, ALT - in 45%, and creatinin in 60%. Moreover, the results were issued in different units. The coefficient of variation (CV) was used to assess the convergence, reproducibility and accuracy of measurements of laboratory parameters in the control material and patient samples. The results of the study showed that its value exceeded the recommended maximum permissible coefficient of variation when measuring concentration levels for more than half of the studied components.
本研究的目的是以上述塔什干地区多个区域临床诊断实验室为例，评估实验室研究的质量、存在问题的领域及潜在改进措施，以及各实验室获得的实验室分析数据的可比性。我们评估了塔什干地区40家临床诊断实验室的检验质量。对血液的9项生化参数进行了质控。在我们使用对照血清的研究中，结果令人堪忧：在测定总胆红素（OB）和葡萄糖时误差为50%，只有30%的实验室获得了正确结果；40%的实验室胆红素结果不可靠，45%的实验室谷丙转氨酶（ALT）结果不可靠，60%的实验室肌酐结果不可靠。此外，结果以不同单位给出。变异系数（CV）用于评估对照物质和患者样本中实验室参数测量的一致性、可重复性和准确性。研究结果表明，在测量超过一半的研究成分的浓度水平时，其值超过了推荐的最大允许变异系数。
