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用于磁场驱动热化疗和双重刺激响应药物输送的非磁性可注射植入物:用于癌症治疗的可变形液态金属杂化平台。

Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics.

机构信息

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

出版信息

Small. 2019 Apr;15(16):e1900511. doi: 10.1002/smll.201900511. Epub 2019 Mar 26.


DOI:10.1002/smll.201900511
PMID:30913375
Abstract

Transformable liquid metal (LM)-based materials have attracted considerable research interest in biomedicine. However, the potential biomedical applications of LMs have not yet been fully explored. Herein, for the first trial, the inductive heating property of gallium-indium eutectic alloy (EGaIn) under alterative magnetic field is systematically investigated. By virtue of its inherent metallic nature, LM possesses excellent magnetic heating property as compared to the conventional magnetite nanoparticles, therefore enabling its unique application as non-magnetic agents in magnetic hyperthermia. Moreover, the extremely high surface tension of LM could be dramatically lowered by a rather facile PEGylation approach, making LM an ideal carrier for other theranostic cargos. By incorporating doxorubicin (DOX)-loaded mesoporous silica (DOX-MS) within PEGylated LM, a magnetic field-driven transformable LM hybrid platform capable of pH/AFM dual stimuli-responsive drug release and magnetic thermochemotherapy are successfully fabricated. The potential application for breast cancer treatment is demonstrated. Furthermore, the large X-ray attenuation ability of LM endows the hybrid with the promising ability for CT imaging. This work explores a new biomedical use of LM and a promising cancer treatment protocol based on LM hybrid for magnetic hyperthermia combined with dual stimuli-responsive chemotherapy and CT imaging.

摘要

基于可变形液态金属(LM)的材料在生物医学领域引起了相当大的研究兴趣。然而,LM 的潜在生物医学应用尚未得到充分探索。在此,首次尝试系统研究镓铟共晶合金(EGaIn)在交变磁场下的感应加热特性。由于其固有的金属性质,与传统的磁铁矿纳米颗粒相比,LM 具有优异的磁加热性能,因此可以将其独特地用作磁热疗中的非磁性试剂。此外,通过相当简单的聚乙二醇化方法可以显著降低 LM 的极高表面张力,使 LM 成为其他治疗试剂的理想载体。通过将载有阿霉素(DOX)的介孔硅(DOX-MS)包封在聚乙二醇化 LM 内,成功制备了一种磁场驱动的可变形 LM 杂化平台,能够实现 pH/原子力显微镜(AFM)双重刺激响应的药物释放和磁热化疗。展示了其在乳腺癌治疗方面的潜在应用。此外,LM 的大 X 射线衰减能力赋予了该杂化物用于 CT 成像的有前途的能力。这项工作探索了 LM 的新的生物医学用途,以及基于 LM 杂化的用于磁热疗联合双重刺激响应化疗和 CT 成像的有前途的癌症治疗方案。

相似文献

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