Kiser R S, German D C, Lebovitz R M
Pharmacol Biochem Behav. 1978 Jul;9(1):27-31. doi: 10.1016/0091-3057(78)90008-4.
Stimulating electrodes were implanted into the dorsal central gray area (DCG) of rats. The animals were trained to bar press to decrement the aversive DCG stimulation current. Rats treated with 5-hydroxytryptophan (5-HTP), 75 mg/kg or 150 mg/kg, showed a dose-dependent reduction in decremental bar pressing. In a second study, animals received either chlorimipramine, 15 mg/kg, protriptyline, 15 mg/kg, or 5-HTP, 150 mg/kg. Chlorimipramine, a strong blocker of serotonin reuptake, and 5-HTP produced significant reductions in decremental bar pressing. Protriptyline, a weak serotonin reuptake blocker, produced no significant effect. These results suggest that serotonin reduces aversive neural mechanisms associated with the dorsal central gray area.
将刺激电极植入大鼠的背侧中央灰质区（DCG）。训练这些动物按压杠杆以减少厌恶的DCG刺激电流。用75毫克/千克或150毫克/千克的5-羟色氨酸（5-HTP）处理的大鼠，其递减式杠杆按压呈现剂量依赖性降低。在第二项研究中，动物分别接受15毫克/千克的氯米帕明、15毫克/千克的普罗替林或150毫克/千克的5-HTP。强效5-羟色胺再摄取阻滞剂氯米帕明和5-HTP使递减式杠杆按压显著减少。弱效5-羟色胺再摄取阻滞剂普罗替林则无显著效果。这些结果表明，5-羟色胺可减少与背侧中央灰质区相关的厌恶神经机制。
