Park W K, Hingtgen J N, Aprison M H
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-4887.
Pharmacol Biochem Behav. 1991 Jan;38(1):191-4. doi: 10.1016/0091-3057(91)90609-6.
The current hypersensitive postsynaptic serotonin receptor theory of depression developed and expanded by Aprison and Hingtgen was based on an animal model of behavior in which food-reinforced approach behavior was suppressed following 5-hydroxytryptophan (5-HTP) administration. In this paper, data are presented to show that when the same animal is taught to emit, alternatingly, approach and avoidance behavior, and the serotonin precursor, 5-HTP, is administered, only the approach behavior is affected. Adult, male Wistar rats were trained on Sidman avoidance (RS20:SS10) and food-reinforced approach (VI 1) schedules. During the first part of this study, rats received separately 50-min sessions for approach and avoidance responding. For the second part, both schedules were given in the same experimental chamber. In the third part, 10-min alternating approach and avoidance components were combined in the same 50-min sessions. Significant behavioral suppression of approach responding was observed following administration of L-5-HTP (50 mg/kg IP), as well as after D,L-5-HTP (25 and 50 mg/kg IP) in a dose-dependent relationship, whereas no significant effect was seen for Sidman avoidance responding during this type of session. These results support the role of serotonin in food-reinforced approach behavior and suggest that suppression of Sidman avoidance behavior may be mediated by other neurotransmitter systems.
由阿普里森和兴特根提出并发展的当前抑郁症超敏突触后血清素受体理论，是基于一种动物行为模型，即给予5-羟色氨酸（5-HTP）后，食物强化的趋近行为会受到抑制。在本文中，所呈现的数据表明，当训练同一只动物交替发出趋近和回避行为，并给予血清素前体5-HTP时，只有趋近行为会受到影响。成年雄性Wistar大鼠接受西曼回避（RS20:SS10）和食物强化趋近（VI 1）训练程序。在本研究的第一部分，大鼠分别接受50分钟的趋近和回避反应训练。在第二部分，两种训练程序在同一实验箱中进行。在第三部分，10分钟的交替趋近和回避部分在相同的50分钟训练时段中组合。腹腔注射L-5-HTP（50mg/kg）以及D,L-5-HTP（25mg/kg和50mg/kg）后，观察到趋近反应出现显著的行为抑制，且呈剂量依赖性，而在此类训练时段中，西曼回避反应未出现显著影响。这些结果支持血清素在食物强化趋近行为中的作用，并表明西曼回避行为的抑制可能由其他神经递质系统介导。
