Mohammad Nur Adlina, Razaly Norfarah Izzaty, Rani Mohd Dzulkhairi Mohd, Aris Muhammad Shamsir Mohd, Effendy Nadia Mohd
Basic Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Menara B, Persiaran MPAJ, Jalan Pandan Utama, Pandan Indah, 55100 Kuala Lumpur, Malaysia.
Malays J Med Sci. 2018 Jul;25(4):6-30. doi: 10.21315/mjms2018.25.4.2. Epub 2018 Aug 30.
Osteoporosis is considered a silent disease, the early symptoms of which often go unrecognised. Osteoporosis causes bone loss, reduces mineralised density, and inevitably leads to bone fracture. Hormonal deficiencies due to aging or drug induction are also frequently attributed to osteoporosis. Nevertheless, the phytochemical content of natural plants has been proven to significantly reduce osteoporotic conditions. A systematic review was conducted by this study to identify research specifically on the effects of Malaysian herbs such as and on osteoporotic bone changes. This review consisted of a comprehensive search of five databases for the effects of specific herbs on osteoporotic bone change. These databases were Web of Science (WOS), Medline, Scopus, ScienceDirect and PubMed. The articles were selected throughout the years, were limited to the English language and fully documented. Duplication, irrelevant titles, different herbs and in vitro studies were excluded, including those that are not original research papers. A total of 399 potential studies were identified, but only 21 samples were accepted based on the inclusion and exclusion criteria. Six of the twenty one studies were on six on and the remaining nine studies were on . Overall, in three of the studies a glucocorticoid-induced model was used, while in 12 of the studies an ovariectomised model was used, and for the other six studies an orchidectomised model was used as the osteoporotic model. All of the studies reported varied results based on the type of herbs used, but in comparison to and recorded better anti-osteoporotic effects, while the majority of studies on were unable to preserve bone strength.
骨质疏松症被认为是一种无声的疾病，其早期症状往往未被识别。骨质疏松症会导致骨质流失，降低骨矿物质密度，并不可避免地导致骨折。衰老或药物诱导引起的激素缺乏也常被认为与骨质疏松症有关。然而，天然植物中的植物化学成分已被证明能显著减轻骨质疏松状况。本研究进行了一项系统综述，以确定专门关于马来西亚草药如[草药名称1]和[草药名称2]对骨质疏松性骨变化影响的研究。该综述全面检索了五个数据库，以查找特定草药对骨质疏松性骨变化的影响。这些数据库分别是科学网（WOS）、医学期刊数据库、Scopus、ScienceDirect和PubMed。选取的文章年份不限，限于英文且记录完整。排除重复、无关标题、不同草药及体外研究，包括那些非原创研究论文。共识别出399项潜在研究，但根据纳入和排除标准仅接受了21个样本。21项研究中有6项是关于[草药名称1]的，6项是关于[草药名称2]的，其余9项研究是关于[草药名称3]的。总体而言，其中3项研究使用了糖皮质激素诱导模型，12项研究使用了卵巢切除模型，另外6项研究使用去势模型作为骨质疏松模型。所有研究均报告了基于所用草药类型的不同结果，但与[草药名称2]和[草药名称3]相比，[草药名称1]记录了更好的抗骨质疏松效果，而大多数关于[草药名称3]的研究未能保持骨强度。
