Simmatis Leif E R, Scott Stephen H, Jin Albert Y
Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Department of Medicine, Queen's University, Kingston, ON, Canada.
Front Behav Neurosci. 2019 Mar 11;13:44. doi: 10.3389/fnbeh.2019.00044. eCollection 2019.
Transient ischemic attack (TIA) was originally defined as self-resolving focal cerebral ischemia with symptoms lasting <24 h. The newer definition also added the limitation that there should be no evidence of acute brain tissue infarction, to recognize that acute injury to the brain can result from ischemia of <24-h duration. However, several recent findings suggest that having a TIA correlates with deficits that can persist far beyond the resolution of clinical symptoms, even in the absence of imaging evidence of ischemic tissue injury. These deficits may be the result of subtle perturbations to brain structure and/or function that are not easily appreciated using the standard clinical and imaging tools that are currently employed in practice. Here, we will discuss evidence that suggests that TIA may lead to lasting changes to the structure and function of the brain.
短暂性脑缺血发作（TIA）最初被定义为症状持续时间小于24小时的自行缓解的局灶性脑缺血。新的定义还增加了一项限制条件，即不应有急性脑组织梗死的证据，以认识到持续时间小于24小时的缺血也可导致脑急性损伤。然而，最近的一些研究结果表明，发生TIA与即使在没有缺血性组织损伤影像学证据的情况下，也可能远远超出临床症状缓解期仍持续存在的功能缺陷相关。这些缺陷可能是脑结构和/或功能发生细微扰动的结果，而使用目前临床实践中采用的标准临床和影像学工具不容易察觉这些扰动。在此，我们将讨论表明TIA可能导致脑结构和功能发生持久变化的证据。
