居住在石棉污染地区的胆管癌患者肝脏中石棉纤维的鉴定：一项初步研究。
Asbestos fiber identification in liver from cholangiocarcinoma patients living in an asbestos polluted area: a preliminary study.
作者信息
Grosso Federica, Croce Alessandro, Libener Roberta, Mariani Narciso, Pastormerlo Massimo, Maconi Antonio, Rinaudo Caterina
机构信息
Mesothelioma Unit, Oncology, SS Antonio e Biagio e Cesare Arrigo, General Hospital, Alessandria, Italy.
Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.
出版信息
Tumori. 2019 Oct;105(5):404-410. doi: 10.1177/0300891619839305. Epub 2019 Mar 27.
PURPOSE
To assess whether asbestos fibers may be observed in liver tissue of patients with cholangiocarcinoma (CC) with environmental or working asbestos exposure.
METHODS
Detection of fibers was performed directly on histologic sections of liver from 7 patients with CC using optical microscope and variable pressure scanning electron microscopy equipped with energy-dispersive spectroscopy (VP-SEM/EDS). All patients were from Casale Monferrato, Italy, a highly asbestos-polluted town. Due to ethical constraints, observers were blinded to patients' clinical features.
RESULTS
Fibers/bundles of fibers of chrysotile were detected in 5 out of 7 patients (71%). The boundary between healthy and neoplastic tissue or the fibrocollagen tissue produced by the neoplasia were identified as areas of fiber incorporation.
CONCLUSIONS
This study is the first report about the detection of chrysotile asbestos fibers in the liver of patients with CC. Further studies on larger cohorts are needed to corroborate our preliminary findings.
目的
评估在有环境或工作中石棉暴露史的胆管癌（CC）患者的肝组织中是否能观察到石棉纤维。
方法
使用光学显微镜和配备能谱仪的可变压力扫描电子显微镜（VP-SEM/EDS），直接对7例CC患者的肝脏组织切片进行纤维检测。所有患者均来自意大利卡萨莱蒙费拉托，这是一个石棉污染严重的城镇。由于伦理限制，观察者对患者的临床特征不知情。
结果
7例患者中有5例（71%）检测到温石棉纤维/纤维束。健康组织与肿瘤组织之间的边界或肿瘤形成的纤维胶原组织被确定为纤维掺入区域。
结论
本研究是关于在CC患者肝脏中检测到温石棉纤维的首次报告。需要对更大的队列进行进一步研究以证实我们的初步发现。
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