Chu I, Villeneuve D C, Yagminas A, Valli V E
J Environ Sci Health B. 1986 Jun;21(3):229-42. doi: 10.1080/03601238609372520.
Control and phenobarbital (PB) or polychlorinated biphenyl (PCB) pretreated rats were given single oral doses of 14C-1,2,4,5-tetrachlorobenzene (TCB) at 30 or 300 mg/kg b.w. Urine and feces were collected daily for the determination of 14C-content. Five animals per group were killed 2 days after dosing and another five animals were killed 7 days later for the determination of hepatic microsomal enzyme activities, histological changes and 14C-content in the major organs and tissues. Pretreatment with PCB or PB did not alter the effects of TCB biochemically or histologically. Both PB and PCB increased the rate of TCB excretion and decreased the levels of radioactivity in most tissues examined at 7 days after dosing. It was concluded that, at the dose ranges studied, pretreatment with PB or PCB did not significantly alter the toxic effects produced by TCB.
对对照组以及经苯巴比妥（PB）或多氯联苯（PCB）预处理的大鼠，分别按30或300 mg/kg体重经口单次给予14C-1,2,4,5-四氯苯（TCB）。每天收集尿液和粪便以测定14C含量。给药后2天处死每组5只动物，7天后再处死另外5只动物，用于测定肝微粒体酶活性、组织学变化以及主要器官和组织中的14C含量。PCB或PB预处理在生化或组织学方面均未改变TCB的作用。PB和PCB均提高了TCB的排泄率，并降低了给药7天后所检测的大多数组织中的放射性水平。得出的结论是，在所研究的剂量范围内，PB或PCB预处理并未显著改变TCB产生的毒性作用。
