Correa-Oliveira R, James S L, McCall D, Sher A
J Immunol. 1986 Sep 15;137(6):2014-9.
Mice of most inbred strains develop moderate to high levels of resistance to challenge infection on vaccination with radiation-attenuated cercariae of Schistosoma mansoni. P strain mice, however, fail to display significant protective immunity after exposure to the same vaccine. To examine the genetic basis of this polymorphism in host immunity, vaccine-induced resistance was examined in (C57/BL6J X P/N)F1, F2, and reciprocal backcross generations. The defective immunity which characterizes the P strain parent was found to be inherited in a fully recessive manner and to be controlled by a single genetic locus, which we have designated Rsm-1. Linkage analyses revealed that Rsm-1 is not genetically associated with the major histocompatibility complex (chromosome 17), the immunoglobulin heavy chain locus (chromosome 12), or a single locus influencing defective anti-schistosomulum IgM antibody responses in the P parental stock. These data provide the first example of single gene control of vaccine-induced immunity against a helminth infection. Because P mice are also defective in their capacity to develop tumoricidal macrophages and in their immunity to Leishmania major, genes encoded by the Rsm-1 locus may play a general role in resistance to infection and malignancy.
大多数近交系小鼠在用曼氏血吸虫辐射减毒尾蚴接种后，会对攻击感染产生中度到高度的抵抗力。然而，P品系小鼠在接触相同疫苗后，却未能表现出显著的保护性免疫。为了研究宿主免疫中这种多态性的遗传基础，我们在（C57/BL6J×P/N）F1、F2和正反交回交世代中检测了疫苗诱导的抗性。发现P品系亲本所特有的免疫缺陷以完全隐性的方式遗传，并由一个单一的基因座控制，我们将其命名为Rsm-1。连锁分析表明，Rsm-1与主要组织相容性复合体（第17号染色体）、免疫球蛋白重链基因座（第12号染色体）或影响P亲本群体中抗血吸虫幼虫IgM抗体反应缺陷的单个基因座没有遗传关联。这些数据提供了第一个由单基因控制针对蠕虫感染的疫苗诱导免疫的例子。由于P小鼠在产生杀肿瘤巨噬细胞的能力以及对利什曼原虫的免疫方面也存在缺陷，Rsm-1基因座编码的基因可能在抵抗感染和恶性肿瘤方面发挥普遍作用。
