使用瞬态导向基团实现饱和醛的脱氢β-芳基化反应
Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups.
作者信息
Zhang Xing-Long, Pan Gao-Fei, Zhu Xue-Qing, Guo Rui-Li, Gao Ya-Ru, Wang Yong-Qiang
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science , Northwest University , Xi'an 710069 , People's Republic of China.
出版信息
Org Lett. 2019 Apr 19;21(8):2731-2735. doi: 10.1021/acs.orglett.9b00695. Epub 2019 Mar 27.
An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde β-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C═C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.
已开发出一种前所未有的饱和醛β-C-H与芳烃的交叉脱氢偶联（CDC）反应，通过四个C-H键的裂解形成肉桂醛。该反应对C═C双键具有完全的E-立体选择性。该方法具有原子经济性和步骤经济性、温和的反应条件以及操作简便的特点。
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