Okimura T, Ogawa M, Yamauchi T, Sasaki Y
Jpn J Pharmacol. 1986 Jun;41(2):237-45. doi: 10.1254/jjp.41.237.
We investigated the correlation between restraint stress-induced alteration of antibody responses and adrenal hormones. Adrenalectomy (Adx) blocked both the suppression of antibody response against T cell-dependent (TD) antigen and the enhancement of that against T cell-independent (TI) antigen in stressed mice. Adx also inhibited the atrophy of both thymus and spleen caused by restraint. Pre-treatment of metyrapone, an inhibitor of adrenocortical steroid biosynthesis, had an effect that was similar to, but far weaker than that of Adx on stressed mice. The pre-administration of phenoxybenzamine, an alpha-adrenergic blocking agent, to mice prevented both the inhibition of antibody response to TD antigen and the decrease in spleen cell number of restrained mice. A similar effect was observed in mice pre-treated with 6-hydroxydopamine, an adrenergic neuron degenerating agent. However, no effects of these two agents were observed on the enhancement of antibody response to TI antigen. The suppressive effect of the antibody response to TD antigen was augmented by the pre-administration of propranolol, a beta-adrenergic blocking agent. These results suggest that the suppression of the function of T cells in restrained mice are attributed to the released adrenocortical and adrenal medullary hormones and activated sympathetic nervous system and that the enhancement of B cell function is due to the adrenocortical hormones.
我们研究了束缚应激诱导的抗体反应改变与肾上腺激素之间的相关性。肾上腺切除术（Adx）阻断了应激小鼠中针对T细胞依赖性（TD）抗原的抗体反应抑制以及针对T细胞非依赖性（TI）抗原的抗体反应增强。Adx还抑制了束缚引起的胸腺和脾脏萎缩。肾上腺皮质类固醇生物合成抑制剂美替拉酮预处理对应激小鼠的作用与Adx相似，但远弱于Adx。给小鼠预先施用α-肾上腺素能阻断剂酚苄明可防止对TD抗原的抗体反应抑制以及束缚小鼠脾细胞数量的减少。在用肾上腺素能神经元变性剂6-羟基多巴胺预处理的小鼠中也观察到类似的效果。然而，未观察到这两种药物对TI抗原抗体反应增强有影响。β-肾上腺素能阻断剂普萘洛尔预先给药增强了对TD抗原的抗体反应抑制作用。这些结果表明，束缚小鼠中T细胞功能的抑制归因于释放的肾上腺皮质和肾上腺髓质激素以及激活的交感神经系统，而B细胞功能的增强则归因于肾上腺皮质激素。
