Mihajlovic Dunja, Brkic Snezana, Lendak Dajana, Mikic Aleksandra Novakov, Draskovic Biljana, Mitic Gorana
Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Emergency Center, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for Infectious Diseases, Novi Sad, Serbia.
Biomark Med. 2019 Apr;13(5):341-351. doi: 10.2217/bmm-2018-0282. Epub 2019 Mar 28.
The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers. A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Development of septic shock and 28-day mortality were assessed. Endocan and thrombomodulin showed better discriminative power than procalcitonin for the presence of sepsis. Endocan showed good discriminative power for septic shock prediction. Addition of endocan significantly contributed to sequential (sepsis-related) organ failure assessment score in logistic regression model. Endothelial biomarkers have a good diagnostic potential for sepsis. Endocan is useful as a predictor of the severity and fatality of sepsis.
我们研究的目的是比较内皮生物标志物与传统使用的生物标志物在符合Sepsis-3标准的脓毒症患者中预测严重程度和预后的效用。我们的研究共纳入了150例患者。患者被分为两组：脓毒症患者和感染性全身炎症反应综合征患者。评估了感染性休克的发生情况和28天死亡率。对于脓毒症的存在，内脂素和血栓调节蛋白比降钙素原具有更好的鉴别能力。内脂素在预测感染性休克方面具有良好的鉴别能力。在逻辑回归模型中，加入内脂素显著提高了序贯（脓毒症相关）器官衰竭评估评分。内皮生物标志物对脓毒症具有良好的诊断潜力。内脂素可作为脓毒症严重程度和死亡率的预测指标。
