Department of Clinical Laboratory Center, The second Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
Second Provincial People's Hospital of Gansu, Lanzou, Gansu 730000, China.
Environ Toxicol Pharmacol. 2019 Jul;69:16-25. doi: 10.1016/j.etap.2019.02.007. Epub 2019 Mar 14.
Cytochrome P450 17A1 (CYP17A1; EC: 1.14.14.19) is a critically important bifunctional enzyme with nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor that catalyzes the formation of all endogenous androgens. Its hydroxylase activity catalyzes the 17α-hydroxylation of pregnenolone (PREG)/progesterone (P4) to 17α-OH-pregnenolone/17α-OH-progesterone, and its 17,20-lyase activity converts 17α-OH-pregnenolone/17α-OH-progesterone to dehydroepiandrosterone/androstenedione. Androgens are required for male reproductive development, so androgen deficiency resulting from CYP17A1 inhibition may lead to reproductive disorders. There has been some advances on the study of environmental chemicals inhibiting mammalian CYP17A1 expression but no related review was available so we think it now necessary to review their characteristics and inhibiting properties.
细胞色素 P450 17A1（CYP17A1；EC：1.14.14.19）是一种重要的双功能酶，以烟酰胺腺嘌呤二核苷酸磷酸（NADPH）为辅助因子，催化所有内源性雄激素的形成。其羟化酶活性催化孕烯醇酮（PREG）/孕酮（P4）的 17α-羟化生成 17α-OH-孕烯醇酮/17α-OH-孕酮，其 17,20-裂合酶活性将 17α-OH-孕烯醇酮/17α-OH-孕酮转化为脱氢表雄酮/雄烯二酮。雄激素对于男性生殖发育至关重要，因此 CYP17A1 抑制导致的雄激素缺乏可能导致生殖障碍。目前已经有一些关于环境化学物质抑制哺乳动物 CYP17A1 表达的研究进展，但没有相关的综述，因此我们认为现在有必要对它们的特性和抑制特性进行综述。
