Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Food Chem Toxicol. 2019 Jun;128:46-53. doi: 10.1016/j.fct.2019.03.043. Epub 2019 Mar 25.
Human placental CYP19A1 catalyzes the estrogen synthesis from androgens. The enzyme is encoded by CYP19A1 gene located in chromosome 15q21. This enzyme is a monooxygenase in the smooth endoplasmic reticulum. The various promoters of the CYP19A1 gene determine its expression in different tissues and the distal promoter I.1 controls its expression in the placenta and retinoids can regulate the expression. Many food components and environmental chemicals inhibit CYP19A1 activity via different modes of action. These chemicals include gossypol, flavones, flavanones, chalconoids, resveratrol, and tobacco alkaloids derived from foods as well as phthalates, insecticides, fungicides, and biocides in the contaminated foods. The inhibition of placental CYP19A1 could impair pregnancy.
人类胎盘 CYP19A1 可催化雄激素合成雌激素。该酶由位于染色体 15q21 的 CYP19A1 基因编码。这种酶是内质网光滑表面的单加氧酶。CYP19A1 基因的不同启动子决定了其在不同组织中的表达，而远端启动子 I.1 控制其在胎盘组织中的表达，类视黄醇可以调节其表达。许多食物成分和环境化学物质通过不同的作用模式抑制 CYP19A1 的活性。这些化学物质包括棉酚、黄酮类、黄烷酮类、查耳酮类、白藜芦醇和烟草生物碱，它们来自食物，邻苯二甲酸酯、杀虫剂、杀真菌剂和受污染食物中的杀生剂也是如此。胎盘 CYP19A1 的抑制作用可能会损害妊娠。
