Sprengers E D, Akkerman J W, Jansen B G
Thromb Haemost. 1986 Jun 30;55(3):325-9.
An assay for plasminogen activator inhibitor in human platelets is described. With this assay we find an average value of 6.8 X 10(-8) IU/platelet (S.D. = 3.0 X 10(-8); n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibitor might have a different physiologic function.
本文描述了一种检测人血小板中纤溶酶原激活物抑制剂的方法。通过该检测方法，我们在健康人群中发现纤溶酶原激活物抑制剂的平均值为6.8×10⁻⁸IU/血小板（标准差=3.0×10⁻⁸；n=20）。我们对血小板中的纤溶酶原激活物抑制剂进行了特性分析，并通过其免疫学和功能特性将其鉴定为内皮细胞型纤溶酶原激活物抑制剂。除了具有非常高周转率的血浆纤溶酶原激活物抑制剂池外，血小板在循环中构成了数量级相同的第二个纤溶酶原激活物抑制剂池。两种不同的纤溶酶原激活物抑制剂池可能具有不同的生理功能。
