Caudill Megan N, Stilwell Justin M, Howerth Elizabeth W, Garner Bridget
Department of Pathology, University of Georgia, Athens, Georgia.
Vet Clin Pathol. 2019 Mar;48(1):67-70. doi: 10.1111/vcp.12700.
A 4-year-old, spayed female French Bulldog was presented for respiratory distress and suspected aspiration pneumonia after oral administration of activated charcoal for possible ingestion of a suspected toxic dose of trazodone. The patient had a moderate volume of pleural effusion, which contained free and intracellular black particulate matter consistent with charcoal. Due to presumed charcoal aspiration with subsequent lung rupture, the right middle and right caudal lung lobes were surgically removed. Histology revealed abundant black debris consistent with charcoal and severe granulomatous inflammation. Based on the clinical, gross, and histologic findings, a diagnosis of severe, chronic, locally extensive, aspiration pneumonia and lung rupture with secondary pleuritis and mediastinitis due to charcoal aspiration was made. Aspiration pneumonia is the main complication of activated charcoal administration, which can incite extensive, granulomatous inflammation in the respiratory tract. To the authors' knowledge, this is the first report describing the cytologic and histologic findings associated with inadvertent charcoal aspiration in a veterinary species.
一只4岁已绝育的雌性法国斗牛犬因在口服活性炭以处理可能摄入疑似中毒剂量曲唑酮后出现呼吸窘迫和疑似吸入性肺炎前来就诊。该患犬有中等量的胸腔积液，其中含有与活性炭相符的游离和细胞内黑色颗粒物。由于推测为活性炭吸入并随后导致肺破裂，右侧中叶和右侧尾叶肺被手术切除。组织学检查显示有大量与活性炭相符的黑色碎片以及严重的肉芽肿性炎症。根据临床、大体和组织学检查结果，诊断为严重的、慢性的、局部广泛的吸入性肺炎以及因活性炭吸入导致肺破裂继发胸膜炎和纵隔炎。吸入性肺炎是活性炭给药的主要并发症，可引发呼吸道广泛的肉芽肿性炎症。据作者所知，这是第一份描述兽医物种中意外活性炭吸入相关细胞学和组织学检查结果的报告。
