Department of Surgical and Perioperative Science, Umeå University, Umeå, Sweden.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
Acta Paediatr. 2019 Oct;108(10):1867-1870. doi: 10.1111/apa.14801. Epub 2019 Apr 15.
Hirschsprung disease is usually treated during infancy. The long-term impact on mental health has not been well studied. The aim of this study was to assess the risk for depressive disorders in individuals with Hirschsprung disease.
This was a nationwide, population-based cohort study. The study exposure was Hirschsprung disease and the study outcome was depression. The exposed cohort included all individuals with Hirschsprung disease, registered in the Swedish National Patient Register between 1964 and 2013 and the unexposed cohort included ten age- and sex-matched controls per patient. The diagnosis of depression was confirmed by diagnosis in the Swedish National Patient Register.
The cohort included 739 (76.5% males) individuals with Hirschsprung disease and 7390 (76.5% males) controls. Among the patients with Hirschsprung disease, 35 (4.7%) of the patients had had a depressive disorder and 187 (2.5%) of controls, hazard ratio 1.98, 95% confidence interval 1.38-2.84. The mean age at diagnosis of first depression was 21.9 years (SD ± 7) in Hirschsprung disease patients and 23.4 years (SD ± 7), p = 0.236 in the unexposed group. There were no significant gender differences.
We found an increased risk of having depressive disorders among individuals with Hirschsprung disease compared to controls.
先天性巨结肠症通常在婴儿期进行治疗。其对心理健康的长期影响尚未得到充分研究。本研究旨在评估先天性巨结肠症患者发生抑郁障碍的风险。
这是一项全国性的基于人群的队列研究。研究暴露为先天性巨结肠症，研究结局为抑郁障碍。暴露队列包括在 1964 年至 2013 年期间在瑞典国家患者登记处登记的所有先天性巨结肠症患者，每个患者匹配 10 名年龄和性别相匹配的对照者，组成未暴露队列。抑郁障碍的诊断通过瑞典国家患者登记处的诊断得到确认。
该队列包括 739 名（76.5%为男性）先天性巨结肠症患者和 7390 名（76.5%为男性）对照者。在先天性巨结肠症患者中，35 名（4.7%）患者患有抑郁障碍，187 名（2.5%）对照者患有抑郁障碍，风险比为 1.98，95%置信区间为 1.38-2.84。先天性巨结肠症患者首次诊断出抑郁障碍的平均年龄为 21.9 岁（SD ± 7），未暴露组的平均年龄为 23.4 岁（SD ± 7），p = 0.236。性别间无显著差异。
与对照组相比，我们发现先天性巨结肠症患者发生抑郁障碍的风险增加。
