Thorner M O, Vance M L, Evans W S, Ho K, Rogol A D, Blizzard R M, Furlanetto R, Rivier J, Vale W
Acta Endocrinol Suppl (Copenh). 1986;276:34-40. doi: 10.1530/acta.0.111s0034.
Growth hormone-releasing factor (GRF) is found in the highest concentration (albeit lower compared to other hypothalamic regulatory hormones) in the hypothalamus. There is mounting evidence that GRF-like immunoreactivity is found in other sites in the CNS and in the periphery. The role of GRF, other than to stimulate growth hormone secretion by the somatotroph, is unknown. In addition generation of IGF-1 in response to GRF appears to be dependent on an intact pituitary.
生长激素释放因子（GRF）在下丘脑中浓度最高（尽管与其他下丘脑调节激素相比浓度较低）。越来越多的证据表明，在中枢神经系统和外周的其他部位也发现了GRF样免疫反应性。除了刺激生长激素细胞分泌生长激素外，GRF的作用尚不清楚。此外，对GRF作出反应生成胰岛素样生长因子-1似乎依赖于完整的垂体。
