Department of Occupational Health Engineering, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Ecotoxicol Environ Saf. 2019 Jul 30;176:132-136. doi: 10.1016/j.ecoenv.2019.03.079. Epub 2019 Mar 27.
In this study, occupational exposure to volatile organic compounds (VOCs) in the rendering plant of poultry slaughterhouse was determined and subsequently, carcinogen and non-carcinogenic risks were assessed using the US Environmental Protection Agency (USEPA). National Institute for Occupational Safety and Health (NIOSH) methods of 1501 and 1600 were used to measure VOCs in the breathing zone of the workers. Samples were analyzed by GC/MS. Carcinogenic and non-carcinogenic risks and sensitivity analysis were carried out using Monte Carlo simulations technique. The concentration of benzene and CS was higher than the occupational exposure limits (OEL). The hazard quotient (HQ) values for all measured compounds was more than 1, which indicating the high potential for non-carcinogenic risks. Furthermore, the calculated Lifetime Cancer Risks (LCR) for carcinogenic compounds revealed that cancer risk due to benzene is higher than the maximum acceptable level provided by USEPA (10). Based on the sensitivity analysis, the concentration and exposure frequency are the most important variable influencing both carcinogen and non-carcinogenic risks. Therefore, the concentration levels of the VOCs and exposure frequency should be controlled using engineering control measures.
在这项研究中，测定了家禽屠宰场炼油厂工人接触挥发性有机化合物（VOC）的情况，并随后使用美国环境保护署（USEPA）和美国国家职业安全与健康研究所（NIOSH）的 1501 和 1600 方法，评估了致癌和非致癌风险。使用 GC/MS 对样品进行分析。使用蒙特卡罗模拟技术进行致癌和非致癌风险以及敏感性分析。苯和 CS 的浓度高于职业暴露限值（OEL）。所有测量化合物的危害系数（HQ）值均大于 1，这表明存在较高的非致癌风险。此外，致癌化合物的计算终生癌症风险（LCR）表明，由于苯引起的癌症风险高于 USEPA 规定的最高可接受水平（10）。基于敏感性分析，浓度和暴露频率是影响致癌和非致癌风险的最重要变量。因此，应使用工程控制措施控制 VOC 的浓度水平和暴露频率。
