锂对情感障碍患者神经内分泌功能的影响。

The effects of lithium on neuroendocrine function in affectively ill patients.

作者信息

Joffe R T, Post R M, Ballenger J C, Rebar R, Gold P W

出版信息

Acta Psychiatr Scand. 1986 May;73(5):524-8. doi: 10.1111/j.1600-0447.1986.tb02720.x.

DOI:10.1111/j.1600-0447.1986.tb02720.x

Abstract

Lithium is the primary treatment for manic-depressive illness. The mechanism of action of lithium and its endocrine effects remain unclear. Therefore, the hormone responses to sequential stimuli, namely arginine, TRH, and LHRH, were studied in eight patients with major depression before and during treatment with lithium. The drug was found to elevate baseline TSH and prolactin and to augment both their responses to TRH. No clinically significant effect on sex hormones was noted. The advantages of the experimental design and the implications of the findings for lithium's mechanism of action are discussed.

摘要

锂是治疗躁郁症的主要药物。锂的作用机制及其内分泌效应仍不清楚。因此，我们对8例重度抑郁症患者在锂治疗前和治疗期间对精氨酸、促甲状腺激素释放激素（TRH）和促性腺激素释放激素（LHRH）等连续刺激的激素反应进行了研究。发现该药物可提高基础促甲状腺激素（TSH）和催乳素水平，并增强它们对TRH的反应。未观察到对性激素有临床显著影响。本文讨论了实验设计的优点以及研究结果对锂作用机制的启示。