蛹草拟青霉（Paecilomyces hepiali；CBG-CS-2）菌丝体提取物的免疫调节作用：一项随机双盲临床试验。
Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial.
机构信息
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea.
Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Republic of Korea.
出版信息
BMC Complement Altern Med. 2019 Mar 29;19(1):77. doi: 10.1186/s12906-019-2483-y.
BACKGROUND
Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults.
METHODS
Healthy adults were divided into the intervention group (n = 39), who were given 1.68 g/day of CBG-CS-2 in capsules, and the control group (n = 40) for 8 weeks. The activities of natural killer (NK) cells and serum levels of monocyte-derived mediators were assessed initially for a baseline measurement and after 8 wks.
RESULTS
The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from the baseline of NK cell cytotoxic activity relative to the placebo group after the administration of the capsules for 8 wks. (P < 0.019).
CONCLUSION
The results suggest that the immune system functions well with CBG-CS-2 supplementation, perhaps with less accompanying inflammation. Thus, CBG-CS-2 is safe and effective for enhancing cell-mediated immunity in healthy adults.
TRIAL REGISTRATION
This study was registered at Clinical Trials.gov ( NCT 02814617 ).
背景
蛹虫草是一种传统的中药，具有多种生物制药作用，包括增强免疫力的作用。在这项研究中，我们制备了蛹虫草菌丝体培养提取物（蝙蝠蛾拟青霉，CBG-CS-2），以确认其在增强免疫系统方面的功效，并评估其在健康成年人中的安全性。
方法
将健康成年人分为干预组（n=39），给予 CBG-CS-2 胶囊 1.68g/天，对照组（n=40）持续 8 周。最初评估自然杀伤（NK）细胞的活性和单核细胞衍生介质的血清水平作为基线测量，然后在 8 周后进行评估。
结果
与安慰剂组相比，在给予 CBG-CS-2 胶囊 8 周后，NK 细胞细胞毒性活性的基线水平提高了 38.8±17.6%（P<0.019）。
结论
结果表明，CBG-CS-2 补充剂可使免疫系统正常运作，可能伴随的炎症较少。因此，CBG-CS-2 对增强健康成年人的细胞介导免疫是安全有效的。
试验注册
本研究在 ClinicalTrials.gov 上注册（NCT 02814617）。
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