Institute of Biostructures and Bioimaging, Italian National Research Council, Napoli, Italy.
Institute of Biostructures and Bioimaging, Italian National Research Council, Napoli, Italy.
Phys Med. 2019 Mar;59:75-78. doi: 10.1016/j.ejmp.2019.02.005. Epub 2019 Mar 4.
To present a new formalism for a robust computation of Dose-Surface Histograms (DSHs) to be exploited in the analysis of surface effects in radiation induced toxicity phenomena.
A new formal recipe for the DSH extraction is described. It is based on the computation of the Dose-Volume Histogram (DVH) on a 3D structure in the limit of vanishing thickness to approach the two-dimensional organ manifold. The theory is customized for the application to skin description.
The derived formalism resulted in a redefinition of the generalized equivalent uniform dose (gEUD) and, accordingly, in an extension of the scope of the classical Lyman-Kutcher-Burman (LKB) Normal Tissue Complication Probability (NTCP) to a DSH-based toxicity modeling.
Our approach properly fits the intrinsic 3D nature of the DSH computation issue, and guarantees the rotational invariance and the robustness of the results. The proposed formalism can be easily implemented in treatment planning systems for dose optimization and potentially paves the way to a consistent analysis of radiation-induced morbidity endpoints related to surface effects in hollow organs.
提出一种新的形式主义方法，用于稳健地计算剂量-表面直方图（DSH），以便在分析辐射诱导毒性现象中的表面效应时使用。
描述了一种新的 DSH 提取形式公式。它基于在厚度趋于零时在 3D 结构上计算剂量-体积直方图（DVH），以接近二维器官流形。该理论针对皮肤描述进行了定制。
所得到的形式主义导致了广义等效均匀剂量（gEUD）的重新定义，并且相应地，将经典的 Lyman-Kutcher-Burman（LKB）正常组织并发症概率（NTCP）的范围扩展到基于 DSH 的毒性建模。
我们的方法很好地适应了 DSH 计算问题的内在 3D 性质，并保证了结果的旋转不变性和稳健性。所提出的形式主义可以很容易地在治疗计划系统中实现，用于剂量优化，并有可能为与中空器官表面效应相关的辐射诱导发病率终点的一致分析铺平道路。
