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哈维·库欣对诺曼·多特关于肢端肥大症工作的影响:1900 年至 1960 年间的垂体研究、治疗方式和研究传播。

Harvey Cushing's Influence on Norman Dott's Work on Acromegaly: Pituitary Research, Treatment Modalities, and Research Dissemination c.1900-c.1960.

机构信息

Neurosurgery Department, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom.

University of Manchester, Manchester, United Kingdom.

出版信息

World Neurosurg. 2019 Jul;127:e8-e15. doi: 10.1016/j.wneu.2019.01.038. Epub 2019 Mar 28.

DOI:10.1016/j.wneu.2019.01.038
PMID:30928575
Abstract

OBJECTIVE

To review Dr. Harvey Cushing's influence on Mr. Norman Dott's work on acromegaly and other subjects surrounding the pituitary gland such as pituitary research, treatment modalities, and research dissemination. Dott was the first Professor of Neurosurgery in Scotland during 1947 and was considered a pioneer of the understanding and treatment modalities for pituitary disorders such as acromegaly. During 1923, he published an article regarding pituitary physiology that won him the award for the Rockefeller Fellowship Trust, to travel to Boston Massachusetts, giving him the opportunity to train under Cushing's supervision for the years of 1923-1924. However, similarities can be seen between Dott's physiology project that was completed before he ever met Cushing, as well as his treatment suggestions for acromegaly, after he had finished his training under Cushing's supervision.

METHODS

This was a historical perspective based on literature review. We reviewed Norman Dott's archives held by University of Edinburgh Library or online sources and we compared these with the work Cushing had previously performed in a chronological fashion. Cushing's work on the pituitary gland and acromegaly can be largely found online, in biographical books, and in other secondary sources. The search included words such as "transsphenoidal surgery," "x-ray," "Harvey Cushing," "Norman Dott," "Acromegaly," "Annual Meetings," and "Pituitary physiology." We excluded any primary sources that were not published between 1900 and 1960 regarding either pituitary physiology or the treatments for acromegaly.

CONCLUSIONS

Sir Norman Dott was the first Professor of Neurosurgery in Scotland during 1947 and is well known for his pioneering work on intracranial aneurysms. Although less well known for his contribution to pituitary pathologies, we would like to share his contribution in this regard and correlate it with Cushing's influence.

摘要

目的

回顾哈维·库欣博士对诺曼·多特博士在肢端肥大症和其他与垂体相关主题(如垂体研究、治疗方法和研究传播)方面工作的影响。多特博士于 1947 年担任苏格兰第一位神经外科教授,被认为是理解和治疗肢端肥大症等垂体疾病的先驱之一。1923 年,他发表了一篇关于垂体生理学的文章,该文章为他赢得了洛克菲勒奖学金信托基金的奖项,使他有机会在马萨诸塞州波士顿接受库欣的监督培训,为期 1923-1924 年。然而,在多特博士从未见过库欣之前完成的生理学项目以及他在库欣监督下完成培训后对肢端肥大症的治疗建议之间,可以看到一些相似之处。

方法

这是基于文献回顾的历史观点。我们查阅了爱丁堡大学图书馆或在线资源中保存的诺曼·多特档案,并按时间顺序与库欣之前的工作进行了比较。库欣关于垂体和肢端肥大症的工作可以在网上、传记书籍和其他二手资料中找到。搜索词包括“经蝶窦手术”、“X 射线”、“哈维·库欣”、“诺曼·多特”、“肢端肥大症”、“年度会议”和“垂体生理学”。我们排除了任何 1900 年至 1960 年之间未发表的关于垂体生理学或肢端肥大症治疗的原始资料。

结论

诺曼·多特爵士于 1947 年担任苏格兰第一位神经外科教授,以其对颅内动脉瘤的开创性工作而闻名。尽管他对垂体病理学的贡献鲜为人知,但我们希望分享他在这方面的贡献,并将其与库欣的影响联系起来。

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