Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Department of Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
J Neurol Sci. 2019 May 15;400:129-134. doi: 10.1016/j.jns.2019.03.022. Epub 2019 Mar 25.
Parkinson's disease (PD) does not present with motor symptoms until dopaminergic neuronal loss exceeds 50%. This might indicate that a network-level compensatory mechanism involving surviving regions in PD acts to reduce brain abnormalities. In contrast, there is no evidence of a compensatory mechanism in multiple system atrophy (MSA). We hypothesized that a comparison of these two diseases would help to identify compensatory effects in PD.
We recruited 23 patients with PD, 11 patients with MSA, and 11 controls that showed an aging brain but no neurological deficits. All subjects underwent resting state functional magnetic resonance imaging (fMRI). Regions of interest were defined according to the motor network related to the basal ganglia and cerebellum. Network-level analyses were performed.
Network-based statistical analyses revealed that functional connectivity in PD brains was reduced between cerebellar lobules IX on both sides and vermis X, as compared with MSA brains. Transitivity was reduced in MSA as compared with controls.
We demonstrated that a part of the intra-cerebellar connectivity was reduced in PD, and that network segregation was reduced in MSA. However, there was no evidence of compensatory effects in PD.
帕金森病（PD）直到多巴胺能神经元丧失超过 50%才出现运动症状。这可能表明 PD 中涉及存活区域的网络级补偿机制可降低大脑异常。相比之下，多系统萎缩（MSA）中没有证据表明存在补偿机制。我们假设对这两种疾病进行比较有助于确定 PD 中的补偿作用。
我们招募了 23 名 PD 患者、11 名 MSA 患者和 11 名表现出衰老大脑但无神经功能缺损的对照者。所有受试者均接受静息状态功能磁共振成像（fMRI）检查。根据与基底节和小脑相关的运动网络定义感兴趣区。进行了网络级分析。
基于网络的统计分析显示，与 MSA 大脑相比，PD 大脑两侧小脑小叶 IX 与小脑蚓部 X 之间的小脑功能连接降低。与对照组相比，MSA 的传递性降低。
我们证明 PD 中一部分小脑内连接减少，MSA 中网络分离减少。然而，PD 中没有证据表明存在补偿作用。
