Department of Radiology, University of Minnesota Medical School, Mayo Mail Code 292, 420 Delaware Street S.E., Minneapolis, MN, 55455, USA.
, Minneapolis, USA.
Abdom Radiol (NY). 2019 Jul;44(7):2535-2544. doi: 10.1007/s00261-019-01970-z.
To validate the application of a magnetic resonance imaging (MRI)-based lobar classification of benign prostatic hyperplasia (BPH) for use in research and clinical management.
Two radiologists with 5 and 11 years post-fellowship experience were trained in the lobar classification of BPH using an internally developed atlas of prostate anatomy with example MRI images edited by a third senior radiologist designated as the "administrator" of the study. A study population of 140 patients referred to a tertiary academic medical center with known or suspected prostate cancer was selected by the administrator to test the interrater reliability (IRR; precision) of the classification as well as accuracy of the two readers compared to the administrator as the "gold" standard. The intrarater reliability of repeat readings of the administrator was also examined. Percentage of agreement, proportion of agreement, and Cohen's κ were applied. This was a retrospective IRB-approved study.
IRR (precision) between the two interpreting radiologists was 64% agreement, corresponding to unweighted κ of 0.52. Composite proportion of agreement across all BPH types (categories) for interpreting radiologists was 0.67. Observer accuracy was 62% agreement, unweighted κ 0.49, for observer 1 and 67%, unweighted κ 0.58, for observer 2. Intrarater reliability for the administrator was 87% agreement, unweighted κ 0.81 with composite proportion of agreement across all categories of 0.87.
MRI lobar classification of BPH is a reproducible and reliable tool for research and clinical applications.
验证磁共振成像（MRI）为基础的前列腺增生（BPH）叶分类在研究和临床管理中的应用。
两位具有 5 年和 11 年的 fellowship后经验的放射科医生，使用内部开发的前列腺解剖图谱以及由指定为该研究的“管理员”编辑的示例 MRI 图像进行 BPH 叶分类培训。管理员选择了 140 名因已知或疑似前列腺癌而转诊至三级学术医疗中心的患者作为研究人群，以测试分类的观察者间可靠性（IRR；精度）以及两名读者相对于管理员作为“金标准”的准确性。管理员重复阅读的观察者内可靠性也进行了检查。应用了百分比一致性、比例一致性和 Cohen's κ。这是一项回顾性 IRB 批准的研究。
两位解释放射科医生之间的 IRR（精度）为 64%的一致性，对应加权 κ 为 0.52。所有 BPH 类型（类别）的解释放射科医生的复合一致性比例为 0.67。观察者 1 的一致性为 62%，加权 κ 为 0.49，观察者 2 的一致性为 67%，加权 κ 为 0.58。管理员的观察者内可靠性为 87%的一致性，加权 κ 为 0.81，所有类别中的复合一致性比例为 0.87。
MRI 前列腺增生叶分类是一种可重复和可靠的研究和临床应用工具。
