[硫喷妥钠在人体中的应用。通过液相色谱和质谱法测定血浆和尿液中的该药物及其代谢物]

[Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry].

作者信息

Bory C, Chantin C, Boulieu R, Cotte J, Berthier J C, Fraisse D, Bobenrieth M J

出版信息

C R Acad Sci III. 1986;303(1):7-12.

Abstract

Thiopental is an anaesthetic drug which is currently used for cerebral resuscitation. In this last indication the drug is administrated at high doses over a period of several days. Under clinical trials thiopental and two metabolites namely 5 ethyl-5 (1' methyl-3' hydroxy-butyl) 2 thiobarbituric acid and 5 ethyl-5 (1' methyl-3' carboxy-propyl) 2 thiobarbituric acid have been determined by high performance liquid chromatography and mass spectrometry. In human plasma high concentrations of thiopental and 5 ethyl-5 (1' methyl-3' hydroxy-butyl) 2 thiobarbituric acid and a lower concentration of 5 ethyl-5 (1' methyl-3' carboxy-propyl) 2 thiobarbituric acid have been found. In urine samples these metabolites are excreted in large and approximately equal quantities, whereas small amounts of thiopental were recovered.

摘要

硫喷妥钠是一种麻醉药物，目前用于脑复苏。在这最后的适应症中，该药物在数天内以高剂量给药。在临床试验中，已通过高效液相色谱法和质谱法测定了硫喷妥钠及其两种代谢产物，即5-乙基-5-(1'-甲基-3'-羟基丁基)-2-硫代巴比妥酸和5-乙基-5-(1'-甲基-3'-羧基丙基)-2-硫代巴比妥酸。在人体血浆中，已发现高浓度的硫喷妥钠和5-乙基-5-(1'-甲基-3'-羟基丁基)-2-硫代巴比妥酸以及较低浓度的5-乙基-5-(1'-甲基-3'-羧基丙基)-2-硫代巴比妥酸。在尿液样本中，这些代谢产物大量且排泄量大致相等地排出，而回收的硫喷妥钠量很少。