Karakaya Muharrem, Albayrak Sinan, Pehlivanoglu Seren, Ozkaya Abdullah, Gocgil Nur Acar
Department of Ophthalmology, Yeniyuzyil University Medical Faculty, Istanbul, Turkey.
Department of Ophthalmology, Surp Pirgic Armenian Hospital, Istanbul, Turkey.
Saudi J Ophthalmol. 2019 Jan-Mar;33(1):56-60. doi: 10.1016/j.sjopt.2018.10.008. Epub 2018 Oct 27.
To compare the efficacy of 5-fluorouracil (5-FU) added the infusion fluid with a control group in the event of grade C PVR in recurrent retinal detachment (RD).
The records of the patients with recurrent retinal detachment with grade C PVR who underwent vitrectomy for retinal detachment surgery between April 2003 and October 2004 were reviewed retrospectively for this comparative study. The recurrent retinal detachment patients with grade C PVR who underwent vitrectomy and had a minimum post-operative follow-up period of 12 months were included. The patients were divided into two groups as study and control groups. 5-FU (200 microgram/ml) and low-molecular-weight-heparin (LMWH) (5 IU/ml) was added into the infusion solution of the study group. Primary outcome measure of this study was the single operation anatomical success at month 12.
A total of 43 eyes of 43 patients were included. The control group was consisted of 26 eyes (60.5%) and the 5-FU group was consisted of 17 eyes (39.5%). At month 12, single operation anatomical success was obtained in 14 of the 26 patients (53.8%) in the control group and in 16 of the 17 patients (94.1%) in the 5-FU group (p = 0.005).
Favorable outcomes were obtained in the patients with recurrent RD and grade C PVR in whom 5-FU and LMWH added infusion fluid which was used during vitrectomy.
比较在复发性视网膜脱离（RD）出现C级增殖性玻璃体视网膜病变（PVR）时，在输液中添加5-氟尿嘧啶（5-FU）与对照组的疗效。
对2003年4月至2004年10月期间因视网膜脱离行玻璃体切除术的C级PVR复发性视网膜脱离患者的记录进行回顾性研究，以进行该对比研究。纳入行玻璃体切除术且术后随访至少12个月的C级PVR复发性视网膜脱离患者。将患者分为研究组和对照组。研究组的输液溶液中添加了5-FU（200微克/毫升）和低分子肝素（LMWH）（5国际单位/毫升）。本研究的主要结局指标是12个月时单次手术的解剖学成功率。
共纳入43例患者的43只眼。对照组有26只眼（60.5%），5-FU组有17只眼（39.5%）。在第12个月时，对照组26例患者中有14例（53.8%）获得单次手术解剖学成功，5-FU组17例患者中有16例（94.1%）获得成功（p = 0.005）。
在玻璃体切除术中使用添加了5-FU和LMWH的输液的复发性RD和C级PVR患者中获得了良好的结果。
