鉴定鼻腔鼻窦未分化癌的新型诊断标志物。
Identification of novel diagnostic markers for sinonasal undifferentiated carcinoma.
机构信息
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Head Neck. 2019 Aug;41(8):2688-2695. doi: 10.1002/hed.25748. Epub 2019 Apr 1.
BACKGROUND
Sinonasal undifferentiated carcinoma (SNUC) is a rare, highly aggressive cancer. It is often difficult to determine whether SNUC is a distinct pathologic entity with poorly differentiated neuroendocrine features or it represents an undifferentiated tumor of squamous lineage. Also, reliable histopathologic markers that distinguish SNUC from poorly differentiated sinonasal squamous cell carcinoma (SNSCC) are lacking. Therefore, identification of new diagnostic molecular markers for SNUC is needed.
METHODS
Treatment-naïve tumor specimens obtained from 15 SNUC and 6 SNSCC patients were used. Gene expression analysis was performed using an oncology panel.
RESULTS
An unsupervised cluster analysis divided the patients into the one with only SNUCs and the one with mainly SNSCCs. Of 132 differentially expressed genes, 7 genes completely distinguished SNUCs from SNSCCs. SNUCs were enriched in sets of genes related to DNA repair, synthesis/replication, and cell division.
CONCLUSIONS
Our study identified new diagnostic markers and potential therapeutic targets for SNUC.
背景
鼻腔鼻窦未分化癌（SNUC）是一种罕见的、侵袭性很强的癌症。通常很难确定 SNUC 是否是一种具有低分化神经内分泌特征的独特病理实体，还是代表具有未分化鳞状细胞谱系的肿瘤。此外，缺乏可靠的组织病理学标志物来区分 SNUC 和低分化鼻腔鼻窦鳞状细胞癌（SNSCC）。因此，需要鉴定 SNUC 的新诊断分子标志物。
方法
使用了 15 名 SNUC 和 6 名 SNSCC 患者的未经治疗的肿瘤标本进行基因表达分析。采用肿瘤面板进行了基因表达分析。
结果
无监督聚类分析将患者分为仅 SNUC 组和主要 SNSCC 组。在 132 个差异表达基因中，有 7 个基因完全区分了 SNUC 和 SNSCC。SNUC 富集了与 DNA 修复、合成/复制和细胞分裂相关的基因集。
结论
我们的研究为 SNUC 鉴定了新的诊断标志物和潜在的治疗靶点。
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