Bonifacio A F, Alunno A, La Paglia G M C, Valentini E, Leone M C, Bartoloni E, Gerli Roberto
Rheumatology Unit, Department of Medicine, University of Perugia.
Reumatismo. 2019 Apr 1;71(1):1-12. doi: 10.4081/reumatismo.2019.1102.
Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA.
类风湿因子和抗环瓜氨酸肽抗体是类风湿关节炎（RA）的诊断标志。然而，在过去几十年中，人们还发现了许多其他自身抗体。一些蛋白质在其天然形式下就能引发异常的自身免疫反应，而另一些蛋白质则在翻译后修饰（如瓜氨酸化、氨甲酰化或乙酰化）后获得这一特性。有趣的是，催化此类翻译后修饰的酶（如蛋白质精氨酸脱氨酶）在RA中也能转变为自身抗体。这篇综述文章的目的是概述过去几年发表的关于新型自身抗体及其在RA中可能的诊断和预后意义的相关文献。
