From the Department of Psychiatry,Université de Montréal,Montreal, Quebec,Canada.
Institut universitaire en santé mentale de Montréal,Montreal, Quebec,Canada.
Can J Neurol Sci. 2019 May;46(3):275-279. doi: 10.1017/cjn.2018.397. Epub 2019 Apr 1.
ABSTRACTAmong healthy volunteers in psychiatric brain functional magnetic resonance imaging (fMRI) research studies, the prevalence of incidentalomas can be as high as 34%, of which 10% show clinical significance. An incidentaloma is a lesion found by coincidence without clinical symptoms or suspicion. Like lesions and other types of accidental findings, it is found in healthy individuals recruited to take part in psychiatric studies. The prevalence of these accidental findings among specific psychiatric populations remains unknown. However, a precise understanding of cerebral neuroanatomy, neuroradiological expertise, and an appropriate choice of fMRI exploration sequences will increase the sensitivity of identifying these accidental findings and enable researchers to address their clinical relevance and nature. We present recommendations on how to appropriately inform patients or participants of the accidental findings. Additionally, we propose specific suggestions pertaining to the clinical research setting aimed for investigators and psychiatrists. Unlike current articles pertaining to incidentaloma, the current report provides a distinct focus on psychiatric issues and specific recommendations for studies involving psychiatric patients.
摘要 在精神科脑功能磁共振成像（fMRI）研究的健康志愿者中，偶然瘤的患病率可高达 34%，其中 10%具有临床意义。偶然瘤是指在没有临床症状或怀疑的情况下偶然发现的病变。与病变和其他类型的偶然发现一样，它是在招募来参与精神科研究的健康个体中发现的。这些偶然发现在特定精神科人群中的患病率尚不清楚。然而，对大脑神经解剖学的精确理解、神经影像学专业知识以及适当选择 fMRI 探索序列将提高识别这些偶然发现的敏感性，并使研究人员能够解决其临床相关性和性质。我们提出了如何适当地告知患者或参与者偶然发现的建议。此外，我们针对研究人员和精神科医生提出了特定的建议，适用于临床研究环境。与目前关于偶然瘤的文章不同，本报告特别关注精神科问题，并为涉及精神科患者的研究提供了具体建议。
