放疗中中度风险前列腺癌的再氧合。
Reoxygenation during radiotherapy in intermediate-risk prostate cancer.
机构信息
Institut de Cancérologie de l'Ouest, Nantes-Saint Herblain, France; Centre de Recherche en Cancéro-Immunologie Nantes/Angers (CRCINA, UMR 892 INSERM), Institut de Recherche en Santé de l'Université de Nantes, Nantes CEDEX 1, France.
Institut de Cancérologie de l'Ouest, Nantes-Saint Herblain, France; Centre de Recherche en Cancéro-Immunologie Nantes/Angers (CRCINA, UMR 892 INSERM), Institut de Recherche en Santé de l'Université de Nantes, Nantes CEDEX 1, France.
出版信息
Radiother Oncol. 2019 Apr;133:16-19. doi: 10.1016/j.radonc.2018.12.022. Epub 2019 Jan 12.
Hypoxia is a major risk factor of prostate cancer radioresistance. We evaluated hypoxia non-invasively, using F-Misonidazole PET/CT prior to radiotherapy and after a dose of 20 Gy in intermediate-risk prostate cancer patients. Decreased hypoxic volumes were observed in all patients, suggesting that radiotherapy induces early prostate tumor reoxygenation.
缺氧是前列腺癌放射抵抗的一个主要危险因素。我们在中危前列腺癌患者放疗前和 20Gy 后使用 F-MISO PET/CT 进行了缺氧的无创评估。所有患者的缺氧体积均减少，提示放疗诱导了早期前列腺肿瘤再氧合。
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