Moutinho-Ribeiro Pedro, Liberal Rodrigo, Macedo Guilherme
Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao and World Gastroenterology Organisation (WGO) Porto Training Center, Porto, Portugal.
Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao and World Gastroenterology Organisation (WGO) Porto Training Center, Porto, Portugal.
Clin Res Hepatol Gastroenterol. 2019 Oct;43(5):513-521. doi: 10.1016/j.clinre.2019.02.014. Epub 2019 Mar 29.
Pancreatic ductal adenocarcinoma is one of the most common causes of cancer-related deaths. Since most patients present with advanced disease, its prognosis is dismal. New and more effective therapeutic strategies are needed. Endoscopic ultrasound is currently an indispensable tool for the diagnosis and staging of pancreatic ductal adenocarcinoma. In recent years, endoscopic ultrasound has evolved to become also a therapeutic procedure. On one hand, the role of endoscopic ultrasound in the management of pancreatic cancer-related symptoms (pain, obstructive jaundice, and gastric outlet obstruction) is now well established. On the other hand, its use as a mean to the delivery of anti-tumor therapies (injecting anti-tumor agents, assisting in radiotherapy, and guiding ablative therapies) is still mostly experimental, despite growing evidence supporting its feasibility, safety and efficacy.
胰腺导管腺癌是癌症相关死亡的最常见原因之一。由于大多数患者就诊时已处于疾病晚期，其预后很差。需要新的、更有效的治疗策略。内镜超声目前是胰腺导管腺癌诊断和分期不可或缺的工具。近年来，内镜超声也已发展成为一种治疗手段。一方面，内镜超声在胰腺癌相关症状（疼痛、梗阻性黄疸和胃出口梗阻）管理中的作用现已得到充分确立。另一方面，尽管越来越多的证据支持其可行性、安全性和有效性，但将其用作抗肿瘤治疗（注射抗肿瘤药物、辅助放疗和引导消融治疗）的一种手段仍大多处于实验阶段。
